The Los Angeles Dodgers are -200 favorites to rebound from Friday night's 7-1 trouncing.
My Dodgers vs. Padres predictions and MLB picks see value in backing them to do just that.
Who will win Dodgers vs Padres today: Los Angeles Dodgers -1.5 (-115)
Yoshinobu Yamamoto has posted an xERA of 3.0 or lower in six of his last seven appearances. He is consistently stringing together quality starts and is about the last pitcher the San Diego Padres would want to see.
They rank dead last in runs per game and have hit just .226 against right-handed pitching in June.
They are unlikely to cause problems for Yamamoto, who pitched seven innings of one-run ball against them in May.
The Los Angeles Dodgers should do damage against Randy Vasquez (6.47 xERA), positioning them to win by multiple runs.
Bet to -125.

Dodgers vs Padres Over/Under pick: Under 8.0 (-110)
Only three of the past 10 head-to-head meetings have gone Over the total, and I expect another low-scoring game in the cards here.
It’ll be very difficult to string together hits against Yamamoto and the Padres lack power for quick-strike offense.
The Dodgers are missing a couple of key bats in Teoscar Hernandez and Will Smith. They’re also playing in a pitcher-friendly park, which will lower their offensive floor and ceiling.
I see this being a 5-2 type of game, and would play the Under to -120.
- ML/RL bets: 44-32, +3.20 units
- Over/Under bets: 40-32-4, +3.99 units
Dodgers vs Padres weather
Temperatures in the high 60s are expected with winds blowing east. Slight boost to the pitchers.
Dodgers vs Padres odds
- Moneyline: Dodgers -200 | Padres +165
- Run line: Dodgers -1.5 (-115) | Padres +1.5 (-105)
- Over/Under: Over 8.0 (-110) | Under 8.0 (-110)
Dodgers vs Padres trend
San Diego has been generous to Under bettors this season, owning a 35-44 O/U record. Find more MLB betting trends for Dodgers vs. Padres.
How to watch Dodgers vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Saturday, June 27, 2026 |
| First pitch | 8:40 p.m. ET |
| TV | SNLA, KFMB-CBS8 |
| Dodgers starting pitcher | Yoshinobu Yamamoto (7-5, 2.65 ERA) |
| Padres starting pitcher | Randy Vasquez (6-5, 4.17 ERA) |
Dodgers vs Padres latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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