Cubs vs Cardinals Prediction, Picks & Odds for Today's MLB Game

Todd Cordell - Betting Analyst at Covers.com
Todd Cordell • Betting Analyst 12+ years betting experience
Updated: Jul 27, 2026 , 11:25 AM ET • 4 min read

The St. Louis Cardinals will tee off on David Peterson for the third time this season.

MLB

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CHC
54 %
STL
46 %
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Jordan Walker St. Louis Cardinals MLB
Photo By - Reuters Connect. St. Louis Cardinals right fielder Jordan Walker (18) hits a single against the Cincinnati Reds

David Peterson's results have improved with the Chicago Cubs, but his underlying numbers remain poor.

I don't think the Chicago Cubs deserve to be -120 favorites with Peterson on the mound, and my Cubs vs. Cardinals predictions and MLB picks on Monday, July 27, reflect that.

Who will win Cubs vs Cardinals today: St. Louis Cardinals (+100)

David Peterson owns a 5.57 ERA, 5.60 SIERA, and 12.6 K% over the last 30 days. He is in horrendous form.

The St. Louis Cardinals have not hit lefties consistently of late, but I’m not sure it matters. They faced Peterson twice recently and combined for 16 runs while knocking him out before completing four innings on both occasions.

Matthew Liberatore has started pitching a little better, conceding three runs or fewer in three of his past four starts — including against the Chicago Cubs.

Back the Cardinals to -110.

Covers COVERS INTEL: Peterson sits at the 19th percentile in K%, playing into the hands of a Cardinals lineup with the second-lowest K% vs. lefties.

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Cubs vs Cardinals Over/Under pick: Over 9.5 (-110)

Opponents are hammering Peterson to the tune of a 44.1% hard-hit rate over the last month, which is the second-highest output among today’s starting pitchers.

Peterson is having a miserable time striking batters out, and the Cardinals excel in avoiding punchouts, making a perfect storm for plenty of good contact.

Liberatore’s 30.2% line-drive rate the past 30 days is alarmingly bad, and doesn’t bode well for his chances of slowing down a Cubs offense sitting in the Top 10 vs. lefties during that stretch.

Bet the Over to -120.

Todd Cordell's 2026 Transparency Record
  • ML/RL bets: 63-55, -4.15 units
  • Over/Under bets: 64-49-5, +6.79 units

Cubs vs Cardinals weather

Temperatures are expected to approach 100 with slight winds blowing out.

Cubs vs Cardinals odds

  • Moneyline: Cubs -120 | Cardinals +100
  • Run line: Cubs -1.5 (+130) | Cardinals +1.5 (-150)
  • Over/Under: Over 9.5 (-110) | Under 9.5 (-110)

Cubs vs Cardinals trend

Chicago has hit the Game Total Over in 18 of the last 30 games (+4.85 units, 15% ROI). Find more MLB betting trends for Cubs vs. Cardinals.

How to watch Cubs vs Cardinals and game info

Location Busch Stadium, St. Louis, MO
Date Monday, July 27, 2026
First pitch 7:35 p.m. ET
TV Marquee Sports Network, Cardinals.TV
Cubs starting pitcher David Peterson
(5-7, 5.97 ERA)
Cardinals starting pitcher Matthew Liberatore
(5-7, 5.18 ERA)

Cubs vs Cardinals latest injuries

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Todd Cordell - Covers
Betting Analyst

Todd Cordell is a data-driven betting analyst. He uses numbers to help identify value across a wide variety of sports, with NHL being his specialty. Shot props, in particular, have proven to be a very fruitful market. Todd has served as a betting analyst in the public sphere for many years, most recently with theScore covering the NHL and MLB.

When not writing about sports betting, Todd stays busy analyzing the New Jersey Devils with a fine-tooth comb for InfernalAccess, his Devils-centric blog. Todd attended Sheridan College and graduated in 2014 with a diploma in print journalism.

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