| Player | POS | Status | |
|---|---|---|---|
| T. Williams | OT | Injured - Rest ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| J. Brendel | OG | Injured - Hamstring ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| C. McCaffrey | RB | Injured - NRI ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| G. Kittle | TE | Injured - Oblique ( Tue, Oct 28) | |
| 
                                        Full Participation In Practice
                                     | |||
| M. Jones | QB | Injured - Knee ( Tue, Oct 28) | |
| 
                                        Full Participation In Practice
                                     | |||
| K. Davis | DL | Injured - Hand ( Tue, Oct 28) | |
| 
                                        Full Participation In Practice
                                     | |||
| B. Huff | DL | Injured - Hamstring ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| J. Elliott | DL | Injured - Ankle ( Tue, Oct 28) | |
| 
                                        Limited Participation In Practice
                                     | |||
| Y. Gross-Matos | DL | Injured - Knee ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| J. Jennings | WR | Injured - Ankle ( Tue, Oct 28) | |
| 
                                        Full Participation In Practice
                                     | |||
| K. White | DL | Injured - NRI ( Tue, Oct 28) | |
| 
                                        Limited Participation In Practice
                                     | |||
| B. Purdy | QB | Injured - Toe ( Tue, Oct 28) | |
| 
                                        Limited Participation In Practice
                                     | |||
| S. Burford | OG | Injured - Knee ( Tue, Oct 28) | |
| 
                                        Full Participation In Practice
                                     | |||
| S. Okuayinonu | DL | Injured - Ankle ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| D. Winters | LB | Injured - Knee ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| B. Bartch | OG | Injured - Ankle ( Tue, Oct 28) | |
| 
                                        Limited Participation In Practice
                                     | |||
| R. Pearsall | WR | Injured - Knee ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| U. Stout | CB | Injured - Shoulder ( Tue, Oct 28) | |
| 
                                        Limited Participation In Practice
                                     | |||
| A. Collins | DL | Injured - Shoulder ( Tue, Oct 28) | |
| 
                                        Did Not Participate In Practice
                                     | |||
| Offense | |||
|---|---|---|---|
| POS | # | Player | |
| QB | 10 | Mac Jones | |
| RB | 23 | Christian McCaffrey | |
| WR | 15 | Jauan Jennings | |
| WR | 84 | Kendrick Bourne | |
| TE | 85 | George Kittle | |
| FB | 44 | Kyle Juszczyk | |
| OT | 71 | Trent Williams | |
| OG | 61 | Matt Hennessy | |
| OG | 68 | Colton McKivitz | |
| OG | 75 | Connor Colby | |
| OG | 77 | Dominick Puni | |
| Defense | |||
|---|---|---|---|
| POS | # | Player | |
| LB | 48 | Tatum Bethune | |
| LB | 53 | Dee Winters | |
| LB | 57 | Luke Gifford | |
| DL | 91 | Sam Okuayinonu | |
| DL | 92 | Jordan Elliott | |
| DL | 93 | Kalia Davis | |
| DL | 98 | Mykel Williams | |
| CB | 0 | Renardo Green | |
| CB | 2 | Deommodore Lenoir | |
| S | 6 | Malik Mustapha | |
| S | 27 | Ji'Ayir Brown | |