The Niners are coming off a one-sided loss to a very stout Houston team and while San Francisco stays on the road – travelling all the way to New Jersey for a 1 p.m. ET kickoff – it’s in a much better spot than the Giants. New York suffered a gutting loss at Philadelphia on Sunday, not just getting slammed by a vengeful defending champion but watching electric rookie RB and unofficial mascot Cam Skattebo go down with a gruesome ankle injury. While the G-Men are losing bodies, the 49ers are getting them back. Quarterback Brock Purdy has a good shot at returning under center after another week of practice and the pressure of Sunday’s loss forcing a change at QB. New York’s defense was already dealing with injuries in Week 8 and could be down two starting defensive backs. The Giants have allowed 26, 33 and 38 points in three of their last four contests.