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Best NFL Picks Today

Find the best NFL bets today - Sept. 27, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

ARI logo
ARI
ARI

20.94 @ 26.77

SF
SF logo
SF

Cardinals vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ARI logo
ARI
ARI

20.94

+7.5 -105

o48.0 -110

+340

SF logo
SF
SF

26.77

-7.5 -105

u48.5 -110

-380

Minnesota @ Tampa Bay
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

20.78 @ 21.51

TB
TB logo
TB

Vikings vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

20.78

+1.5 -120

o42.5 -108

-112

TB logo
TB
TB

21.51

-1.5 +100

u43.0 -115

+100

Top Projection Kyler Murray o20.5 Rushing Yards (-116)
o20.5-113
Baltimore @ Dallas
Matchup Stats

Predicted Score

BAL logo
BAL
BAL

25.21 @ 26.28

DAL
DAL logo
DAL

Ravens vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

BAL logo
BAL
BAL

25.21

-3.5 +100

o52.5 -114

-166

DAL logo
DAL
DAL

26.28

+3.5 -110

u53.5 -110

+155

Top Projection Rashod Bateman o43.5 Receiving Yards (-110)
o43.5-110
Las Vegas @ New Orleans
Matchup Stats

Predicted Score

LV logo
LV
LV

21.06 @ 26.35

NO
NO logo
NO

Raiders vs Saints · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

21.06

+3.5 -115

o43.5 -110

+160

NO logo
NO
NO

26.35

-3.5 +100

u44.0 -112

-177

Top Projection Michael Mayer Score a Touchdown (Yes: +350)
+425
L.A. Rams @ Denver
Matchup Stats

Predicted Score

LA logo
LA
LA

22.61 @ 23.35

DEN
DEN logo
DEN

Rams vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LA logo
LA
LA

22.61

-1.5 -110

o43.5 -120

-125

DEN logo
DEN
DEN

23.35

+1.5 -105

u44.5 -115

+113

Top Projection Bo Nix o217.5 Passing Yards (-105)
o207.5-117
Philadelphia @ Chicago
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

22.29 @ 19.39

CHI
CHI logo
CHI

Eagles vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

22.29

-3.5 -113

o41.5 -105

-185

CHI logo
CHI
CHI

19.39

+3.5 -105

u42.0 -112

+180

Top Projection D'Andre Swift o10.5 Receiving Yards (-115)
o9.5-120
Arizona Cardinals image thumbnail ARI @ San Francisco 49ers image thumbnail SF Sun, Sep 27 • 4:05 PM ET
Anytime Touchdown
Deebo Samuel Sr. logo Deebo Samuel Sr. Score a Touchdown (Yes: +181)
Best Odds
Pick made: yesterday
Geoff Clark logo
Geoff Clark
Betting Analyst

Deebo Samuel's target share should increase with the injuries to San Francisco's WR corps. Also, Deebo is used in the ground game and has 22 career rushing touchdowns in the regular season and playoffs. 

Receptions Made
Christian McCaffrey logo Christian McCaffrey o4.5 Receptions Made (-116)
Best Odds
Pick made: 2 days ago
Geoff Clark logo
Geoff Clark
Betting Analyst

McCaffrey has a team-high 12 targets this season and led San Francisco with 102 catches last season. It was his third season with 100+ receptions. CMC caught five passes in Week 1 and caught at least five passes in 14 of his 19 regular-season and playoff games last season.

View 15 Picks
Minnesota Vikings image thumbnail MIN @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 27 • 4:05 PM ET
Passing Yards
Kyler Murray logo Kyler Murray u199.5 Passing Yards (+114)
Best Odds
Pick made: 2 days ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Murray is expected to return under center after Carson Wentz guided Minnesota to a pair of victories in his absence. Murray managed just 11 snaps in the season opener before exiting with a concussion, and his return comes against a challenging Buccaneers defense that ranks 11th in total defense. I'm giving this defense the benefit of the doubt to shut down a quarterback returning from concussion, and coming off the worst season of his career.

Anytime Touchdown
Bucky Irving logo Bucky Irving Score a Touchdown (Yes: +146)
Best Odds
Pick made: 2 days ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Bucky's red-zone usage alone should make you want to invest in him to score against the Vikings. Minnesota is coughing up 100 yards per game on the ground, and when you add in Irving's volume both as a runner and pass-catcher out of the backfield, it's the perfect storm for him hitting pay dirt for the second time this season.

View 16 Picks
Baltimore Ravens image thumbnail BAL @ Dallas Cowboys image thumbnail DAL Sun, Sep 27 • 4:25 PM ET
Rushing Yards
Javonte Williams logo Javonte Williams u59.5 Rushing Yards (-137)
Best Odds
Pick made: 21 hours ago
Geoff Clark logo
Geoff Clark
Betting Analyst

Javonte Williams is averaging only 3.0 yards per rush, while Baltimore is allowing 3.6. I'm expecting Dallas to lean heavily on Dak Prescott in a shootout, giving Williams fewer carries and two paths to stay Under his rushing total.

Passing Completions
Dak Prescott logo Dak Prescott o25.5 Passing Completions (-103)
Best Odds
Pick made: 22 hours ago
Geoff Clark logo
Geoff Clark
Betting Analyst

I'd take Dak Prescott's pass completion prop up to 28+ in an expected shootout. Dak has attempted 40+ passes in 30 career regular-season games and completed 26+ passes in 27 of them, giving this Over a volume-driven path.

View 22 Picks
Las Vegas Raiders image thumbnail LV @ New Orleans Saints image thumbnail NO Sun, Sep 27 • 4:25 PM ET
Rushing Yards
Tyler Shough logo Tyler Shough o14.5 Rushing Yards (-116)
Best Odds
Pick made: yesterday
Geoff Clark logo
Geoff Clark
Betting Analyst

Tyler Shough has rushed for at least 18 yards in six of his 11 career starts, including 23 yards last week against the Baltimore Ravens. The Saints have the fourth-highest passing rate in the NFL, so Shough should get enough opportunities to scramble.

Anytime Touchdown
Travis Etienne Jr. logo Travis Etienne Jr. Score a Touchdown (Yes: +152)
Best Odds
Pick made: yesterday
Geoff Clark logo
Geoff Clark
Betting Analyst

New Orleans offensive-minded head coach Kellen Moore will find ways to use RB Travis Etienne Jr., who signed a four-year, $48 million deal this offseason. Etienne has 26 career rushing touchdowns and eight receiving touchdowns, including a career-best six receiving scores last season.

View 16 Picks
Los Angeles Rams image thumbnail LA @ Denver Broncos image thumbnail DEN Sun, Sep 27 • 8:20 PM ET
Moneyline
Los Angeles Rams image thumbnail LA (-132)
Best Odds
Pick made: 19 hours ago
Geoff Clark logo
Geoff Clark
Betting Analyst

Los Angeles has the stronger roster nearly everywhere, while Matthew Stafford and Sean McVay give the Rams a clear quarterback-coaching advantage. Denver’s offensive line deserves respect, but I trust the Rams’ talent and experience to overcome home field and Bo Nix.

Anytime Touchdown
Davis Allen logo Davis Allen Score a Touchdown (Yes: +944)
Best Odds
Pick made: 19 hours ago
Geoff Clark logo
Geoff Clark
Betting Analyst

The Rams use two- and three-tight end sets often, and Puka Nacua's likely absence could increase that usage. I'm taking a shot on Davis Allen getting a play-action goal-line target after catching three short-yardage touchdowns last season.

View 26 Picks
Philadelphia Eagles image thumbnail PHI @ Chicago Bears image thumbnail CHI Mon, Sep 28 • 8:15 PM ET
Receiving Yards
Kalif Raymond logo Kalif Raymond o24.5 Receiving Yards (-114)
Best Odds
Pick made: 4 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Bears have a backup at QB, keeping the passing playbook short and conservative. That means plenty of action for slot WR Kalif Raymond. He could poke a hole in this Eagles coverage, that has struggled to contain slot receivers so far in 2026. Philadelphia is giving up the second most fantasy points to the position and Raymond’s projections all sit north of 30 yards with some calling for 40+ on Monday Night Football. Raymond has gone for gains of 84 and 40 yards in this opening two games, catching 13 of 14 balls his way. 

Receiving Yards
D'Andre Swift logo D'Andre Swift o10.5 Receiving Yards (-108)
Best Odds
Pick made: 5 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

It's a backup dump-off kind of Monday with D'Andre Swift projected for 17.5 receiving yards after finishing with five targets last week, including one from Tyson Bagent in his 1.5 drives. Swift is a very underrated pass-catching back with a 50-reception ceiling. With plenty of third-and-longs potentially coming from the backup under center, Swift could see another busy day in the passing game, especially with negative game script. Kyle Monangai was a full go at practice on Friday but has been dealing with a knee injury and has conceded a 65/35 running-back opportunity share to Swift. But the biggest takeaway from Swift's usage is that he dominates the snaps in negative game script, and that sounds like dump-offs to me. The total is 10.5, but I would play the 15-yard line to 50%.

View 17 Picks

For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

How to Use NFL Computer Picks

The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

Free Computer Picks by Odds Shark

Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

Totals (Over/Under)

If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

More NFL Picks & Betting Tools

Our NFL Computer Picks are a great way to place weekly football wagers, but you should also consider handicapping games yourself using some of our other tools. If you're looking to bet on long-term futures this football season, check out some of our other dedicated pages:

Best Football Betting Sites

If you’re ready to bet on NFL picks, you first need to find the right sportsbook. Our NFL betting sites guide offers secure banking, the best odds, bonuses, and reliable customer service options for you.

NFL Free Picks FAQs

When do we release our NFL picks?

Covers NFL picks are released two to three days before each game on the NFL schedule.

What kinds of NFL picks do we make?

Covers provides free NFL picks covering many markets, including point spreads, totals, moneylines, player props, and more.