49ers vs Browns   Results, Match Player Stats & Records

Brock Purdy will be looking for a third consecutive victory, while Shedeur Sanders will be seeking to deliver the Browns their first winning streak of the season when the former low-round draft choices go head-to-head for the first time.

The start will be the 41st for Purdy, the 262nd and final pick of the 2022 draft. He already ranks fourth all-time in touchdown passes among seventh-round picks with 72. That is 71 more than Sanders, the rookie fifth-rounder who notched his first last Sunday in a 24-10 road win over the Las Vegas Raiders.

San Francisco defensive coordinator Robert Saleh is impressed with Sanders, Cleveland's third different starting QB this season.

"You could tell how important it is to him and how much work he's going to put into it," Saleh said. "A guy who's as good as gifted as he is, both physically and mentally, and with the confidence he has, you just know he's going to get better."

Purdy suffered his first career defeat as a starter after 10 straight wins bridging his rookie and second seasons when he was sacked three times and intercepted once in the 49ers' most recent trip to Cleveland, a 19-17 loss in Week 6 of the 2023 campaign.

Now 25 and in his fourth NFL season, he was able to overcome three interceptions when the 49ers (8-4) rode a stingy defense to a 20-9 home win over the Carolina Panthers on Monday night. Purdy was not sacked in the game.

Six days later, he'll have to deal with one of the top defenses in the league. Having held the Raiders to 268 total yards while sacking Geno Smith 10 times, the Browns (3-8) entered the week ranked second in the NFL in yards allowed (273.0) and sacks (42.0).

Myles Garrett was credited with three of the sacks and also forced two fumbles. He had six hits on Smith in all.

"He's the best in the league," Purdy assured reporters this week. "I can't be holding onto the ball too long."

Having recorded four sacks on Baltimore's Lamar Jackson in Week 11, Garrett will be attempting to become the first in the NFL since 1982 (when the stat was first recorded) to register three or more sacks in three straight games.

The San Francisco defense dominated Monday's win over the Panthers. Led by Bryce Huff, who helped pressure Bryce Young into a 169-yard performance, and Ji'Ayir Brown, who intercepted Young twice, the 49ers held an opponent to under 10 points for the first time since a 34-3 win at Jacksonville in November of 2023.

They'll take aim this week at Sanders, who earned a second start after throwing for 209 yards and just one interception against the Raiders.

The son of former 49ers star Deion Sanders expects better of himself this week.

"I'm never comfortable in a situation I'm in," the 23-year-old said. "I always want to exceed expectations, and I always want to grow in each and every week."

The matchup of Purdy and Sanders is the first this season between quarterbacks taken in the fifth round or later.

The 49ers watched the New Orleans Saints' Spencer Rattler, a fifth-round pick in 2024, burn them for three TD passes in Week 2, but that was against former first-rounder Mac Jones, who was subbing for an injured Purdy.

San Francisco will turn to Matt Gay at kicker for the second straight game as Eddy Pineiro was once again ruled out with a right hamstring injury. The 49ers also listed defensive end Sam Okuayinonu (ankle) and linebacker Tatum Bethune (ankle) as out.

The Browns won't have tight end Brenden Bates (ankle), defensive end Alex Wright (quadricep) or defensive tackle Adin Huntington (quadricep). Running back Jerome Ford (hamstring) is questionable.

--Field Level Media