49ers @ Buccaneers Game Overview

Meanwhile, San Francisco is just trying to keep its quarterbacks healthy.

Brock Purdy (toe) will sit out for the fourth time in five games and Mac Jones (knee/oblique) will again attempt to fight through injuries during a Week 6 showdown of 4-1 teams.

Mayfield is coming off a dynamic performance in which he passed for a season-best 379 yards and two touchdowns in a 38-35 road victory over the Seattle Seahawks.

Mayfield hears the praise but hasn't forgotten being discarded earlier in his career. The comeback story is impressive, but he is not getting caught in the chatter.

"At the core, definitely the same, but matured in different ways," Mayfield said Wednesday. "I'm not worried about little things that don't matter. Now if you put it in the landscape of a competitive football game -- in that atmosphere -- that'll never change."

Mayfield ranks fourth in the league with 1,283 passing yards and is tied for third with 10 touchdown passes. He has been intercepted just once in 172 attempts.

His work is proving just enough for the Buccaneers, whose four victories have come by a combined nine points.

The 49ers are 3-0 on the road after posting a 26-23 overtime win against the Los Angeles Rams on Oct. 2. The game ended with San Francisco stuffing a fourth-and-1 run.

"It was a huge character win," 49ers coach Kyle Shanahan said. "... I've really enjoyed these guys since OTAs."

Jones passed for a season-high 342 yards to go with two touchdowns. He was battered throughout the contest, aggravating a knee injury and hurting an oblique. Jones will still carry an injury designation into Sunday's contest as he's listed as questionable on the Friday injury report.

"I can't say enough good things about Mac," Shanahan said.

Kendrick Bourne had a career-high 142 yards while matching his career best of 10 catches against the Rams. The performance came with the 49ers missing key receivers.

Jones and Bourne have a deep familiarity after playing together for three seasons with the New England Patriots.

Tampa Bay remains without longtime standout receiver Mike Evans (hamstring), but rookie wideout Emeka Egbuka has been an immediate force.

Egbuka has 25 receptions for 445 yards and five touchdowns. He is tied for second in the NFL in scoring receptions and ranks fourth in yardage.

Asked Wednesday why he has clicked so well with Egbuka, Mayfield put it in the simplest terms.

"He's just pretty damn good," Mayfield said. "That's just about it."

Mayfield connected with Egbuka on all seven targets vs. Seattle. Egbuka finished with a season-high 163 yards and a touchdown.

"I don't enter any seasons of my life with too many expectations when it comes to statistics or anything really," said Egbuka, the former Ohio State star who was selected with the 19th overall pick of the 2025 draft.

Evans is one of six Tampa Bay players that have been ruled out after Friday's practice. He will sit out for the third straight game.

Also missing Sunday's game are receiver Chris Godwin Jr. (fibula), running back Bucky Irving (foot/shoulder) and cornerbacks Zyon McCollum (thumb) and Benjamin Morrison (hamstring).

Tampa Bay coach Todd Bowles said McCollum underwent a thumb procedure, forcing him to sit out the game.

Purdy is one of five 49ers that have been ruled out. Also sitting out are receivers Ricky Pearsall (knee) and Jordan Watkins (calf) as well as defensive linemen Kevin Givens (pectoral) and Yetur Gross-Matos (knee/hamstring).

San Francisco has won its past four meetings with Tampa Bay, including a 23-20 road victory last November.

--Field Level Media