A couple of NFC West rivals will get after it on Thursday Night Football, with the Seahawks and Cardinals both looking to prove they’re for real.
The host Cardinals are the underdog after originally opening as the favorite, while the total is on the low end at 43.5.
While both teams enter the game at 2-1, my Seahawks vs. Cardinals predictions and NFL picks for September 25 think Arizona might be a bit fraudulent while Seattle is the real deal.
Seahawks vs Cardinals prediction
Seahawks vs Cardinals Best bet: Seahawks moneyline (-120)
After showing some rust in Week 1 vs. the 49ers, the Seattle Seahawks have responded in a big way by destroying both the Steelers and the Saints by a combined score of 75-30.
They’re getting contributions everywhere with strong defensive and special teams play, while Sam Darnold is settling in at QB, with Seattle ranking third in yards per pass attempt so far this season.
This defense has shown a lot of potential early on, which shouldn’t come as a surprise given head coach Mike Macdonald’s track record in Baltimore and at Michigan. Through three games, they haven’t allowed more than 17 points.
The Arizona Cardinals' offense isn’t exactly on fire to start the season, as they rank in the bottom half of the league in both points per game and yards per play.
While it might seem like Arizona is off to a respectable start on the surface, there are plenty of holes we can poke. It’s easy to be skeptical of them after facing an opposing quarterback schedule of Spencer Rattler, Bryce Young, and Mac Jones.
That’s not exactly Pro Bowl-level competition for the Cardinals defense. Despite that, they’ve still allowed the third-most passing yards in the league.
The Seahawks have also owned them in recent seasons, winning each of the last seven against them, most notably holding the Cards to just 24 total points in their two matchups from last season.
Seahawks vs Cardinals TNF same-game parlay
I think Seattle’s path to victory in this matchup will come through the air, so let’s back Darnold and his top pass-catcher to have a substantial impact.
Jaxon Smith-Njigba is building great chemistry with Darnold, as he has back-to-back games with 100+ yards and double-digit targets. He had 77 and 82 yards, respectively, in two games vs. the Cards last season.
Seahawks vs Cardinals 3-leg SGP
- Seahawks moneyline (-120)
- Sam Darnold Over 220.5 passing yards (-115)
- Jaxon Smith-Njigba Over 80.5 receiving yards (-115)
Our big-ticket SGP: McBride's got it made
- Trey McBride torched Seattle for 203 total receiving yards in two games against them last season.
- Seattle has allowed the most catches to tight ends this season and the seventh-most yards.
Seahawks vs Cardinals 4-leg SGP
- Seahawks moneyline (-120)
- Sam Darnold Over 220.5 passing yards (-115)
- Jaxon Smith-Njigba Over 80.5 receiving yards (-115)
- Trey McBride Over 63.5 receiving yards (-115)
Seahawks vs Cardinals odds
- Spread: Seattle -1.5 | Arizona +1.5
- Moneyline: Seattle -120 | Arizona +100
- Over/Under: Over 43.5 | Under 43.5
Seahawks vs Cardinals betting trend to know
The Seahawks have hit the moneyline in seven of their last nine away games (+7.80 Units / 62% ROI). Find more NFL betting trends for Seahawks vs. Cardinals.
How to watch Seahawks vs Cardinals
| Location | State Farm Stadium, Glendale, AZ |
| Date | Thursday, September 25, 2025 |
| Kickoff | 8:15 p.m. ET |
| TV | Amazon Prime |
Seahawks vs Cardinals latest injuries
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