Kyler Murray Odds, Picks & Same-Game Parlay for Thursday Night Football Tonight

James Bisson - Head of Content, Betting
James Bisson • Head of Content, Betting 16+ years betting experience
Updated: Sep 25, 2025 , 01:58 PM ET • 4 min read

Murray and the Cardinals torch the Seahawks under the Thursday Night Football lights.

Kyler Murray Arizona Cardinals NFL
Photo By - Imagn Images. Arizona Cardinals quarterback Kyler Murray (1) throws downfield.

Kyler Murray and the Arizona Cardinals are looking to bounce back from a last-second loss in San Francisco as they host the Seattle Seahawks on Thursday Night Football.

The Seahawks are coming off a 44-13 thrashing of the Saints and 31-17 victory in Pittsburgh after their own loss to the 49ers in Week 1.

My best Kyler Murray odds and prop bets for Thursday, September 24 expect the Cardinals to air it out on Thursday Night Football.

Kyler Murray prop pick

Kyler Murray best bet: Kyler Murray Over 31.5 passing attempts (-125 at bet365)

Arizona Cardinals quarterback Kyler Murray didn’t have to throw the ball too much in the first two weeks of the season, both wins for the Cards. He completed 21 of 29 attempts in Week 1, followed by 17 of 25 attempts in Week 2.

However, the Cardinals turned to Murray for 35 passing attempts (plus one sack) in Week 3, and the gunslinger completed a season-high 22 of those passes.

The Seattle Seahawks have been great against the run this season, limiting the likes of Christian McCaffrey to 69 yards on 22 carries and Alvin Kamara to 18 carries for 42 yards. That’s resulted in quarterbacks Brock Purdy, Aaron Rodgers, and Spencer Rattler throwing 35, 33, and 39 passes.

That shouldn’t be too surprising, and Murray isn’t unfamiliar with that type of game script against the Seahawks.

Last season, Murray went 24 of 37 through the air in Week 12 in Seattle, and then 25 of 38 in Week 14 at home. That should continue in a short week on Thursday Night Football.

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Kyler Murray same-game parlay

Kyler Murray Over 31.5 passing attempts

Kyler Murray Over 1.5 passing TDs

Over 43.5

Murray has thrown for four touchdowns with just one interception through three weeks, which started with a two-touchdown game against the Saints.

The Seahawks have only allowed four touchdown passes through three games as well, but the odds here for Murray to pass for two scores are too high to pass up.

Along with that, we’re going to close out the parlay with the Over 43.5. Both teams are capable of putting up at least 20 points, even on a short week.

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James Bisson
Head of Content, Betting

James Bisson is the Editor-in-Chief at Covers. He has been a writer, reporter and editor for more than 20 years, including a nine-year stint with The Canadian Press and more than five years at theScore. He has covered dozens of marquee events including the 2010 Winter Olympics, the 2006 Stanley Cup final and Wrestlemania 23, and his work has appeared in more than 200 publications, including the Los Angeles Times, the Guardian, Yahoo! Sports, the Toronto Star and The Globe and Mail.

His book, “100 Greatest Canadian Sports Moments”, was a hardcover best-seller in Canada in 2008 and earned him appearances on CBC Radio and Canada AM. He has written more than 50 sportsbook reviews, more than 200 industry news articles, and dozens of other sportsbook-related content articles.

A graduate of the broadcast journalism program at Ryerson University (now Toronto Metropolitan University), James has been an avid bettor since the early 2000s, and cites bet365 as his favorite sports betting site due to its superior functionality and quick payouts. His biggest professional highlight: Covering Canada's first Olympic gold medal on home soil – and interviewing Bret Hart. Twice.

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