Kyler Murray Odds, Picks & Same-Game Parlay for Thursday Night Football

Murray and the Cardinals torch the Seahawks under the Thursday Night Football lights.

Ryan Gilbert - Contributor at Covers.com
Ryan Gilbert • Betting Analyst
Sep 24, 2025 • 14:39 ET • 4 min read
Kyler Murray Arizona Cardinals NFL
Photo By - Imagn Images. Arizona Cardinals quarterback Kyler Murray (1) throws downfield.

Kyler Murray and the Arizona Cardinals are looking to bounce back from a last-second loss in San Francisco as they host the Seattle Seahawks on Thursday Night Football.

The Seahawks are coming off a 44-13 thrashing of the Saints and 31-17 victory in Pittsburgh after their own loss to the 49ers in Week 1.

My best Kyler Murray odds and prop bets for Thursday, September 24 expect the Cardinals to air it out on Thursday Night Football.

Kyler Murray prop pick

Kyler Murray best bet: Kyler Murray Over 31.5 passing attempts (-125 at bet365)

Arizona Cardinals quarterback Kyler Murray didn’t have to throw the ball too much in the first two weeks of the season, both wins for the Cards. He completed 21 of 29 attempts in Week 1, followed by 17 of 25 attempts in Week 2.

However, the Cardinals turned to Murray for 35 passing attempts (plus one sack) in Week 3, and the gunslinger completed a season-high 22 of those passes.

The Seattle Seahawks have been great against the run this season, limiting the likes of Christian McCaffrey to 69 yards on 22 carries and Alvin Kamara to 18 carries for 42 yards. That’s resulted in quarterbacks Brock Purdy, Aaron Rodgers, and Spencer Rattler throwing 35, 33, and 39 passes.

That shouldn’t be too surprising, and Murray isn’t unfamiliar with that type of game script against the Seahawks.

Last season, Murray went 24 of 37 through the air in Week 12 in Seattle, and then 25 of 38 in Week 14 at home. That should continue in a short week on Thursday Night Football.

Kyler Murray same-game parlay

Kyler Murray Over 31.5 passing attempts

Kyler Murray Over 1.5 passing TDs

Over 43.5

Murray has thrown for four touchdowns with just one interception through three weeks, which started with a two-touchdown game against the Saints.

The Seahawks have only allowed four touchdown passes through three games as well, but the odds here for Murray to pass for two scores are too high to pass up.

Along with that, we’re going to close out the parlay with the Over 43.5. Both teams are capable of putting up at least 20 points, even on a short week.

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Ryan Gilbert - Covers
Betting Analyst

Ryan Gilbert brings the passion and pain of being a Philadelphia sports fan. After graduating from Monmouth University with a finance degree, he now uses his statistical background to find inefficiencies in betting markets. With past stops at NHL.com, NBC Sports, and currently at Covers, Ryan's hot picks blend well with the cold ice of a hockey rink.

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