Saturday night brings high stakes, with the NFC’s top seed on the line as the 49ers welcome the Seahawks.
San Francisco escaped with a narrow win in Week 1, though our Seahawks vs. 49ers predictions anticipate a reversal in the finale.
Let's get into our NFL picks before kickoff comes at 8 p.m. ET on Saturday, January 3.
Seahawks vs 49ers predictions
- Seahawks -2.5 (-110 at FanDuel)
- Over 47.5 (-110 at FanDuel)
- Smith-Njigba o7.5 receptions (+114 at FanDuel)
- Jennings anytime TD (+185 at FanDuel)
Seahawks vs 49ers best bets
Seahawks -2.5
Since I'm betting on the Seahawks to get the win, I wouldn't shy away from backing them on the spread with the line sitting at just -2.5.
/
Over 47.5
The first clash between these teams was low-scoring, but I'm expecting far more points in the rematch.
San Francisco is second in the league in offensive success rate but 30th in defensive success rate, and the Over is 6-2 in its last eight games.
Jaxon Smith-Njigba Over 7.5 receptions
Jaxon Smith-Njigba is fourth in the NFL in receptions (113) while the 49ers are 26th in receptions allowed to wide receivers. JSN has logged at least eight catches in 10 of 16 contests, including the previous game against San Fran when he reeled in nine of 13 targets.
Jauan Jennings anytime TD
49ers wide receiver Jauan Jennings has benefited from Purdy’s resurgence, scoring in five straight games and seven of his last eight, including a two-score game against the Titans three weeks ago.
Jennings leads the 49ers with 84 targets on the season, including 19 in the red zone.
It doesn’t matter if it's in the red zone or from just inside field-goal range. Jennings can score in tight spaces or from range.
Bet on the NFL at FanDuel!
Make your NFL bets at FanDuel, America's No. 1 sportsbook! Sign up now and by placing $5 on your first bet, you could win $250 in bonus bets if your wager is a winner!
*Eligible U.S. locations only
Seahawks vs 49ers odds
Seahawks vs 49ers game info
| Location: | Levi's Stadium, Santa Clara, CA |
| Date: | Saturday, 1-3-2026 |
| Kickoff: | 8:00 p.m. ET |
| TV: | ABC/ESPN |
Seahawks vs 49ers latest injuries
Seahawks vs 49ers weather
Monitor gametime conditions with our live NFL weather info and learn how weather impacts NFL betting.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
