The Las Vegas Raiders face the San Francisco 49ers on Sunday in Week 9, and I've identified my best Raiders vs 49ers anytime touchdown picks for the matchup, which kicks off at 4:25 p.m. ET at Levi's Stadium.
Find more betting angles in my NFL picks for Sunday, Nov. 8.
Best Raiders vs 49ers anytime touchdown picks
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| Pick |  Probability |
|---|---|
 Brock Bowers |
44% |
 George Kittle |
55% |
| First TD: Christian McCaffrey |
24% |
| Long shot: Kyle Juszczyk |
16% |
Percentages courtesy of Kalshi, one of the best prediction market apps.
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Raiders touchdown pick: Brock Bowers
Play up to 50%.
Brock Bowers leads the Las Vegas Raiders in numerous categories, including receptions, yards, and touchdowns, with five. He's Kirk Cousins' most reliable target and a physical presence near the goal line.
The University of Georgia product has been heavily targeted in the red zone, and four of his five scores have come inside the 20. Cousins has targeted him 11 times in the red zone this season, despite Bowers playing only six games.
While the San Francisco 49ers have defended opposing tight ends well, Bowers' production is too impressive to overlook. He'll be a factor in Vegas' scoring on Sunday.
49ers touchdown pick: George Kittle
Play up to 60%.
George Kittle is second on the 49ers in touchdowns with five, but he leads the team in receptions and receiving yards. Both Mike Evans and Deebo Samuel are injured, which should mean a massive workload for Kittle on Sunday. I'm backing him to find the end zone.
Kittle is a frequent target near the goal line. He has a 31.3% red zone target share, catching nine of his 11 red-zone targets. Four of his five TDs have come inside the 20 as well.
With 1.6 red-zone targets per game and a depleted San Francisco receiving corps, expect Kittle to be busy in scoring position for the Niners.
First touchdown scorer pick: Christian McCaffrey
Play up to 30%.
Christian McCaffrey continues to be a workhorse for the 49ers, with a team-best eight rushing touchdowns and 34 receptions. CMC has multiple ways to score the first touchdown on Sunday, especially with San Francisco missing numerous offensive weapons.
He's more likely to score on the ground, though. San Francisco ranks eighth in rushing yards, while the Raiders are second-worst in rushing yards allowed. They've struggled to stop the run.
McCaffrey's red-zone numbers are also exceptional. He's responsible for 62.5% of San Francisco's red-zone carries, and seven of his eight touchdowns have come inside the five-yard line. CMC also owns 80% of the team's carries inside the five.
I'm comfortable backing McCaffrey here.
Long-shot touchdown pick: Kyle Juszczyk
Play up to 20%.
Kyle Juszczyk is an intriguing longshot to find the end zone on Sunday against the Raiders. The veteran fullback isn't heavily involved in San Francisco's offense, but his versatility makes him a potential scoring threat, especially near the goal line.
With the 49ers missing several offensive playmakers, Juszczyk could see more opportunities as a pass-catcher. He's capable of slipping out of the backfield for a short touchdown reception, particularly when defenses focus on McCaffrey and Kittle.
Las Vegas has struggled defensively this season, and at a long-shot price, Juszczyk is worth a look as a surprise touchdown scorer, having already found the end zone twice in 2026.
Raiders vs 49ers touchdown combo
I'm backing three of the biggest offensive weapons in this matchup to find the end zone on Sunday. McCaffrey is the safest leg given his dominance near the goal line, while Kittle should benefit from increased opportunities with several San Francisco receivers sidelined.
Bowers is the wildcard here. The Raiders could be playing from behind, forcing Cousins to lean heavily on his favorite target, especially in scoring situations.
This combo relies on the 49ers generating plenty of offensive opportunities while Las Vegas finds a way to score. With all three consistently involved in the red zone, there's plenty of upside.
- TD picks: 0-0
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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