The Arizona Cardinals will try to get out to a 2-0 start when they host the Carolina Panthers at State Farm Stadium on Sunday.
Arizona didn’t exactly look impressive in its Week 1 win, but my Panthers vs. Cardinals predictions still like them to handle a rebuilding Carolina roster.
Let’s take a look at the early lines and which way bettors should lean in my free NFL picks for September 14.
Panthers vs Cardinals predictions
Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.
Early Panthers vs Cardinals spread pick: Cardinals moneyline
The Arizona Cardinals are fresh off an ugly victory over the New Orleans Saints in Week 1, but a win is a win.
Fueled mostly by an excellent effort from the defensive secondary, the Cardinals are set to feast on Bryce Young and the Carolina Panthers.
Once again, Young struggled behind center in Week 1 against the Jacksonville Jaguars, completing just 18 of 35 passes, throwing two interceptions, and losing a fumble. Meanwhile, the Carolina defense did little to stop the Jaguars, with the linebacking corps particularly struggling against the run.
No matter what questions you have about the Cardinals, they’re far more solid than the Panthers. I’m taking Arizona to cover, especially if the line remains under a touchdown.
Early Panthers vs Cardinals total pick: Under 44.5
Arizona's secondary is more than capable of handling Young and his weak crop of receivers, none of whom represent a game-changing threat to opposing defenses.
Meanwhile, Kyler Murray & Co. are coming off a disappointing showing against the Saints, and Carolina was at least somewhat effective at stopping the passing game, holding Trevor Lawrence to 178 yards on 31 attempts.
Although the Cardinals will win this game, I don't expect them to produce 30+ points. Combine that with a hapless Panthers offense, and I like the Under.
Panthers vs Cardinals odds
- Panthers vs. Cardinals spread: Cardinals -4.5
- Panthers vs. Cardinals moneyline: Panthers +180, Cardinals -220
- Panthers vs. Cardinals Over/Under: 46.5
How to watch Panthers vs Cardinals
- Panthers vs. Cardinals matchup
- Date: Sunday, September 14, 2025, 4:05 p.m. ET
- City: Glendale, AZ
- Venue: State Farm Stadium
- TV: CBS
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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