A marquee battle takes place at Arrowhead Stadium tonight, with the Detroit Lions taking on the Kansas City Chiefs.
Detroit will look to win its fifth straight game, while Kansas City aims to rebound from a heartbreaking loss on Monday Night Football.
Here’s our complete breakdown of our Lions vs. Chiefs predictions ahead of their prime-time showdown on NBC.
Lions vs Chiefs SNF predictions
- Mahomes o38.5 pass attempts (-138 at FanDuel)
- Lions +2.5 (-110 at FanDuel)
- Worthy anytime TD (+145 at FanDuel)
- Montgomery o41.5 rushing yards (-114 at FanDuel)
Lions vs Chiefs SNF best bets
Patrick Mahomes Over 38.5 passing attempts
Jason Logan expects Patrick Mahomes to continue to air it out, especially against a blitz-happy Lions defense that’s missing key pieces in the secondary.
"Projections for Week 6 have Mahomes throwing between 34 and 40 passes, with the majority of those models above the 35.5-attempt prop total. Given Detroit’s depleted secondary, the lack of pop from the Chiefs’ ground game, and a game script calling for a shootout, I’m leaning toward the high side of those forecasts."
Detroit Lions +2.5
J-Lo also believes Detroit is being undervalued heading into this marquee battle at Arrowhead.
"Kansas City has to brace for this Lions offense on a short week. Detroit can gash this soft Chiefs run stop defense and won’t miss in the red zone."
Lions vs Chiefs SNF TD picks
Xavier Worthy anytime touchdown
Eric Rosales is bullish on Kansas City speed demon Xavier Worthy reaching paydirt for the first time this season.
"Detroit has been hit with 16 pass plays of 20+ yards and allowed 10 TD passes. Look for Worthy to get behind the defense for a major in this one."
Lions vs Chiefs SNF props
David Montgomery Over 41.5 rushing yards
Rohit Ponnaiya predicts David Montgomery will flex his muscles on the ground for Detroit.
"The Chiefs are 31st in the league in defensive rush EPA while ranking 28th in yards allowed per carry (4.8). The Lions use a lot of outside zone-blocking schemes and duo run concepts, and Kansas City's defense is vulnerable against both run types."
Lions vs Chiefs odds
Lions vs Chiefs game info
| Location: | Arrowhead Stadium, Kansas City, MO |
| Date: | Sunday, October 12, 2025 |
| Kickoff: | 8:20 p.m. ET |
| TV: | NBC |
Lions vs Chiefs latest injuries
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