The Philadelphia Eagles face a tough trip to Highmark to face the Buffalo Bills, who have shown real signs of improvement in recent weeks.
I give you my favorite Eagles vs. Bills anytime touchdown picks below.
Eagles anytime touchdown pick
Saquon Barkley (-105 at FanDuel)
I just can’t escape picking Saquon Barkley. Only the Jets have allowed more touchdowns to opposing running backs this season, with the Buffalo Bills giving up a staggering 20 in 15 games.
It’s their Achilles heel and even with this Philadelphia Eagles offensive line struggling to make the same holes they did for Barkley last year, they should still have joy against this defense.
Barkley has only found the endzone nine times this season, but has found some form in recent weeks. He’s scored in three consecutive games, his longest scoring streak of the year, and will be confident in extending that run against a Buffalo defense that’s allowed a rushing TD in four straight games.

Bills anytime touchdown pick
Dawson Knox (+270 at FanDuel)
James Cook is the obvious choice here with five touchdowns in his past two games, and he has a great chance of scoring, but the odds on offer for Dawson Knox are drawing me in.
The Eagles have been strong against tight ends, but for the Bills, they are the best red zone options, with the team lacking a true WR1.
Knox has the second-most red zone targets on the team — behind only Khalil Shakir — this season, and he has two more than fellow tight end Dalton Kincaid. Over the past three games, we’ve seen him get a lot of focus, with seven red zone targets.
That’s more than Kincaid and Shakir combined in that span. It’s also worth noting that Knox needs one more touchdown to trigger a $100,000 incentive in his contract.
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