Anytime Touchdown Scorer Eagles vs Bills Prediction: TD Picks for Week 17

Despite a quieter season, Saquon Barkley has finished the year strong, and our Eagles vs. Bills anytime touchdown picks expect him to find the end zone this weekend.

Sam Farley - Contributor at Covers.com
Sam Farley • Betting Analyst
Dec 27, 2025 • 16:00 ET • 4 min read
Saquon Barkley Philadelphia Eagles NFL
Photo By - Imagn Images. Saquon Barkley celebrates a touchdown.

The Philadelphia Eagles face a tough trip to Highmark to face the Buffalo Bills, who have shown real signs of improvement in recent weeks.

I give you my favorite Eagles vs. Bills anytime touchdown picks below.

Eagles anytime touchdown pick

Saquon Barkley (-105 at FanDuel)

I just can’t escape picking Saquon Barkley. Only the Jets have allowed more touchdowns to opposing running backs this season, with the Buffalo Bills giving up a staggering 20 in 15 games.

It’s their Achilles heel and even with this Philadelphia Eagles offensive line struggling to make the same holes they did for Barkley last year, they should still have joy against this defense.

Barkley has only found the endzone nine times this season, but has found some form in recent weeks. He’s scored in three consecutive games, his longest scoring streak of the year, and will be confident in extending that run against a Buffalo defense that’s allowed a rushing TD in four straight games.

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Bills anytime touchdown pick

Dawson Knox (+270 at FanDuel)

James Cook is the obvious choice here with five touchdowns in his past two games, and he has a great chance of scoring, but the odds on offer for Dawson Knox are drawing me in.

The Eagles have been strong against tight ends, but for the Bills, they are the best red zone options, with the team lacking a true WR1.

Knox has the second-most red zone targets on the team — behind only Khalil Shakir — this season, and he has two more than fellow tight end Dalton Kincaid. Over the past three games, we’ve seen him get a lot of focus, with seven red zone targets.

That’s more than Kincaid and Shakir combined in that span. It’s also worth noting that Knox needs one more touchdown to trigger a $100,000 incentive in his contract.

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Sam Farley
Betting Analyst

Sam is based in the United Kingdom, where he grew up living and breathing soccer, before discovering - and playing - a different kind of football at the University of Bristol. He’s worked in the media covering soccer and the NFL for the better part of a decade, and has been a regular on the Matchbook NFL Podcast. His work has also appeared in a wide range of publications including The Telegraph, The Independent, VICE, and MSN.

The search for great betting value is a daily one, and Sam always hunts out big prices with a particular focus on player props. Sam’s best advice for bettors is to track their bets on a spreadsheet, that way you can keep an eye on your P&L but also the types of bets and sports that you are most successful in. He also recommends using a variety of different sportsbooks, with bet365, Betfair and Paddy Power amongst his favorites.

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