The misery has been mounting for Joe Burrow and the Cincinnati Bengals amid a lost season, but my Cardinals vs. Bengals predictions believe they can unleash some frustration on Sunday against the Arizona Cardinals, losers of seven in a row.
The Bengals are 7-point favorites in the NFL odds, with the Over/Under total at a lofty 53.5 as we approach kickoff at 1:00 p.m. ET on FOX.
Check out my free NFL picks for this December 28 clash.
Cardinals vs Bengals prediction
Cardinals vs Bengals Best bet: Bengals -7 (-115)
With extra scrutiny around his mood and future in Cincinnati, Joe Burrow had a field day last weekend against the Miami Dolphins. He racked up 309 passing yards that afternoon with four TDs, and a repeat performance is on the cards on Sunday, given the Arizona Cardinals' defensive flaws.
The Cincinnati Bengals have scored 32+ points in three of their past four contests, and I’ll gladly lay the points here, with the slumping Cards just 1-6 ATS in their last seven games despite some gritty efforts from Jacoby Brissett.
There are also 2026 NFL Draft considerations here for the visitors, who enter with a 3-12 record and could slide further towards the No.1 pick.
Arizona has allowed 40+ points in four of its past seven contests — all losses — and I see Cincy coming out swinging here, with a chance to finish the season on a better note.
The Bengals’ last outing at Paycor Stadium was an embarrassing 24-0 thumping at the hands of the Baltimore Ravens, so they’ve got a point to prove.
Burrow and Co. scored 35 straight points in Week 16 in Miami to dial down the panic level, and there are enough injuries on this Cardinals defense to suggest the hosts — playing with total freedom in a game that means nothing for them — will pull away for another comfortable victory.
Cardinals vs Bengals same-game parlay
Tee Higgins has put together a 10-touchdown season despite Cincy’s struggles, and I’m picking him for another score on Sunday. He’s found the end zone eight times in his past seven outings, and Burrow trusts the 6’4 receiver to come down with contested catches.
If the Bengals are going to cruise past the 30-point mark again here, Higgins will be a big part of the game plan.
As bleak as things have looked defensively for the hosts, this passing yards prop feels too high for Jacoby Brissett. He was held to 203 yards last time out against the Atlanta Falcons, completing just 16 of his 31 passes, and Marvin Harrison Jr. remains on the injury report for the Cards.
Cardinals vs Bengals SGP
- Bengals -7
- Tee Higgins anytime touchdown
- Jacoby Brissett Under 252.5 passing yards
Our big-ticket SGP: Trey to da House!
Trey McBride has been a rare bright spot for Arizona this season, piling up 109 catches, and he’s the likeliest candidate to score for the visitors.
McBride already has 10 touchdowns to his name, and he’ll be the top target for Brissett in the red zone.
Cardinals vs Bengals SGP
- Bengals -7
- Tee Higgins anytime touchdown
- Jacoby Brissett Under 252.5 passing yards
- Trey McBride anytime touchdown
Cardinals vs Bengals odds
- Spread: Cardinals +7 (-110) | Bengals -7 (-110)
- Moneyline: Cardinals +290 | Bengals -360
- Over/Under: Over 53.5 (-110) | Under 53.5 (-110)
Cardinals vs Bengals game predictions
Cardinals vs Bengals moneyline prediction
The Cardinals aren’t showing many signs of life after posting a 1-9 mark in their past 10 games, and it’s hard to see them keeping up with all the Bengals’ offensive weapons. Cincinnati cruised to a comfortable victory in the last meeting between these teams, and Arizona’s injury list makes an upset unlikely here.
Cardinals vs Bengals spread prediction
I’ve already made the case for the Bengals to cover the spread, especially with four of the Cards’ last seven losses coming by 19+ points. Though Cincinnati’s defense has been exposed repeatedly this season, I’m sticking with Burrow to outplay Brissett. The Bengals are 4-1 ATS in their past five contests.
Cardinals vs Bengals Over/Under prediction
Both these squads have trended towards the Over this year. It’s 9-6 for Arizona and 8-6-1 for Cincy. There should be points on the menu here, with the Bengals allowing a league-worst 402.8 yards per game and the Cardinals not far behind. And yet the visitors haven’t scored more than 20 points in any of their last four games.
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Cardinals vs Bengals trend to know
The Over is 4-1 in the last five meetings between these teams. Find more NFL betting trends for Cardinals vs. Bengals.
How to watch Cardinals vs Bengals
| Location | Paycor Stadium, Cincinnati, OH |
| Date | Sunday, December 28, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
Cardinals vs Bengals latest injuries
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