Much of sports gambling is not based on one team’s strengths, but on another’s weaknesses. Good luck finding any weaknesses to fade between the Indiana Hoosiers and the Ohio State Buckeyes.
Still, my Indiana vs. Ohio State predictions and college football picks will trust the Buckeyes’ superior talent and depth, not to mention experience. Kickoff between the No. 1 and No. 2 teams in the land comes at 8:00 p.m. ET on Saturday, December 6.
Indiana vs Ohio State predictions for the Big Ten Championship
Who will win the Big Ten Championship?
We live in a world where it would not be terribly shocking to see Indiana upset Ohio State, win the Big Ten title, and be the No. 1 seed in the College Football Playoff. A moneyline underdog of +158 has an implied chance of winning of about 40%. Nothing that has a 40% chance should be considered terribly shocking.
Yet, until we see it happen, will anyone believe it can?
Ohio State has more talent, depth, and experience. Trusting the Buckeyes is the only logical approach in the Big Ten championship.
Indiana vs Ohio State best bet: Ohio State -4.5 (-105)
Good luck finding a flaw in either the Ohio State Buckeyes or the Indiana Hoosiers. Both at 12-0, the two have combined to win just three one-score games this entire season. They blow out opponents, and they do not let stress linger.
But when it comes to exceeding expectations, the Buckeyes do so far more often than the Hoosiers. Ohio State has covered the spread in nine of its 10 games against Power Four competition this year, compared to just a 5-4 ATS record against Power Four foes for Indiana.
The Buckeyes’ ease in dispensing any and all comers should be only strengthened with far fewer nerves remaining. After winning the National Championship last year, no greater stressor existed for Ohio State than the Michigan boogeyman.
But the Buckeyes got rid of that monkey on their back with ease last week. There should be no stress remaining on Ohio State, unlike for Indiana, which very much still needs to prove it belongs in these title conversations.
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Indiana vs Ohio State same-game parlay
In his last 16 games, beginning with "The Game" at the end of the 2024 regular season, Jeremiah Smith has reached the end zone in 12 of them. Two of the exceptions came in five-score blowouts. In a moment that matters most, there are few easier cheat codes than Smith.
Increasingly, Bo Jackson may also be considered a cheat code. The freshman running back has cleared this prop in five straight games. More impressively, he has rushed for at least 105 yards in four of those games; Jackson is doing far more than barely scraping by this yardage mark.
Indiana vs Ohio State SGP
- Ohio State -4.5
- Jeremiah Smith anytime TD
- Bo Jackson Over 72.5 rushing yards
Our deep-ball SGP: Defenses stand tall
Ohio State has a distinct tendency to grind down games that have any tension. Blame Ryan Day or credit him, the habit undoubtedly starts with the Buckeyes head coach.
Ohio State has had four games this season with spreads within two scores, going 4-0 against the spread in those four games and forcing all four Under their totals. Those games fell short of their totals by an average of 14.4 points.
Indiana vs Ohio State SGP
- Ohio State -4.5
- Jeremiah Smith anytime TD
- Bo Jackson Over 72.5 rushing yards
- Under 47.5
Indiana vs Ohio State odds
- Spread: Indiana +4.5 | Ohio State -4.5
- Moneyline: Indiana +158 | Ohio State -188
- Over/Under: Over 47.5 | Under 47.5
Indiana vs Ohio State trend to know
Ohio State is 10-1-1 against the spread this season, the sole ATS loss coming because Purdue scored a touchdown in the final two minutes when trailing by 31 points while the spread was -28.5. Find more college football betting trends for Indiana vs Ohio State.
How to watch Indiana vs Ohio State
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Saturday, December 6, 2025 |
| Kickoff | 8:00 p.m. ET |
| TV | FOX |
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Odds are correct at the time of publishing and are subject to change.
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