The Delaware Blue Hens will be playing their first ever game against an FBS opponent as an FBS team themselves on Saturday afternoon when they face off with Coach Prime and the Colorado Buffaloes at Folsom Field.
It was a rough start for Coach Deion Sanders in his first game without his sons and Travis Hunter. However, they get a big drop off in competition in Week 2.
Find out who I like in my Delaware vs. Colorado predictions and college football picks for Saturday, September 6.
Delaware vs Colorado prediction
Delaware vs Colorado best bet: Colorado -23.5 (-122 at FanDuel)
The Delaware Blue Hens played their first ever game as an FBS team last week against an FCS opponent and won 35-17 over Delaware State. Now they must jump into playing against not only a fellow FBS opponent, but a power conference team.
The last time Delaware played an FBS opponent was September of 2023 when they lost 63-7 at Penn State. While I wouldn’t expect a repeat of that performance, I do believe the Buffaloes are going to take out some frustrations from last week’s loss on the Blue Hens here.
While transfer quarterback Kaidon Salter struggled through the air, he did run the ball well along with running back Micah Welch, who averaged 5.8 yards per carry last week.
Delaware just gave up 200 rushing yards to Delaware State and I am sure Colorado is going to take advantage of that run defense.
The Buffs run defense struggled, but it was mostly to the quarterback runs. The Blue Hens do not have nearly as mobile a quarterback and are a much more pass heavy offense.
Colorado will take out some anger from the way they lost last week and get a big win to spoil Delaware’s first FBS game.
Delaware vs Colorado same-game parlay
To add to the spread, I am going to take the Over. The Blue Hens can probably still get to double digits and then I think Colorado could get near 40.
Also adding Micah Welch to reach the endzone against a bad run defense.
- Colorado -23.5
- Over 49.5
- Micah Welch anytime touchdown
Our deep-ball SGP: TDs for All
Salter had a rushing touchdown last week and had 19 in his two years at Liberty. He can get another one here.
- Colorado -23.5
- Over 49.5
- Micah Welch anytime touchdown
- Kaidon Salter anytime touchdown
Delaware vs Colorado odds
- Spread: Delaware +23.5 (+100) | Colorado -23.5 (-122)
- Moneyline: Delaware +1400 | Colorado -4000
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
Delaware vs Colorado trend to know
Colorado have covered the Spread in nine of their last 13 games. Find more college football betting trends for Delaware vs Colorado.
How to watch Delaware vs Colorado
| Location | Folsom Field |
| Date | Saturday, September 6, 2025 |
| Kickoff | 3:30 p.m. ET |
| TV | FOX |
Delaware vs Colorado latest injuries
Delaware vs Colorado weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
