The Cincinnati Bearcats hit the road for the first time this season to take on the Kansas Jayhawks in a crucial matchup for both programs aiming to jumpstart their Big 12 campaigns.
With both passing attacks poised to challenge the defenses, expect plenty of points on the board. Check out who I’m backing in my Cincinnati vs. Kansas predictions and college football picks for Saturday, September 27.
Cincinnati vs Kansas prediction
Cincinnati vs Kansas best bet: Over 57.5 (-115)
Depth in the secondary could be a major issue for the Kansas Jayhawks in this game, especially in the first half. Safety Devin Dye is suspended for the first half due to a targeting call in the second half of last week’s game. The other starting safety, Mason Ellis, is also doubtful to play due to an injury.
Cincinnati Bearcats quarterback Brendan Sorsby did have some struggles in the opener against Nebraska, but that's a much better defense, and he's played well in the two games since. Against Missouri, this Jayhawks defense allowed 334 yards passing and three touchdowns through the air.
On the other end, sixth-year senior quarterback Jalon Daniels has also been great this year. He's a dual-threat quarterback and will likely be utilized more with running back Daniel Hishaw Jr. doubtful to play with an injury. Cincy allowed 274 yards passing to Bowling Green a few weeks ago.
Cincinnati has allowed 20 points twice this season despite not facing an offense anywhere near the level of Kansas thus far. Kansas allowed 42 points in its one tough game this season. I expect a very high-scoring game with lots of success in the passing game for both teams.
Cincinnati vs Kansas same-game parlay
To add to the Over, I'm going to take both quarterbacks to hit their yardage total and Bearcats wideout Cyrus Allen to hit his receiving total. Allen has surpassed this number in every game this season.
Cincinnati vs Kansas SGP
- Over 57.5
- Jalon Daniels Over 214.5 passing yards
- Brendan Sorsby Over 203.5 passing yards
- Cyrus Allen Over 38.5 receiving yards
Our deep-ball SGP: Go big or go home
Let's add tight end DeShawn Hanika to find the endzone for the Jayhawks. He has three touchdowns this season on 10 catches, so he'll be the red-zone target.
Cincinnati vs Kansas SGP
- Over 57.5
- Jalon Daniels Over 214.5 passing yards
- Brendan Sorsby Over 203.5 passing yards
- Cyrus Allen Over 38.5 receiving yards
- DeShawn Hanika anytime touchdown
Cincinnati vs Kansas game predictions
Cincinnati vs Kansas moneyline prediction
The Jayhawks have more experience, and even though their secondary will struggle, they have the better offense and will win at home.
Cincinnati vs Kansas spread prediction
Most of the sharp money has been on Cincinnati and moved this spread from 5.5 to 4.5.
Cincinnati vs Kansas Over/Under prediction
The Over is getting 68% of the money despite getting only 40% of the bets.
Cincinnati vs Kansas odds
- Spread: Cincinnati +4.5 | Kansas -4.5
- Moneyline: Cincinnati +155 | Kansas -200
- Over/Under: Over 57.5 | Under 57.5
Cincinnati vs Kansas trend to know
Kansas has cashed the first-half Over in 10 of its last 12 games. Find more college football betting trends for Cincinnati vs Kansas.
How to watch Cincinnati vs Kansas
| Location | David Booth Kansas Memorial Stadium, Lawrence, KS |
| Date | Saturday, September 27, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | TNT |
Cincinnati vs Kansas latest injuries
Cincinnati vs Kansas weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
