The Detroit Pistons have rolled without Cade Cunningham, and they’ll look to keep that momentum and complete the season sweep of the Philadelphia 76ers when they head to Xfinity Mobile Arena tonight.
Jalen Duren has feasted without Cunningham in the lineup; my Pistons vs. 76ers predictions call for another big game from the big man.
Here are my best free NBA picks for this Eastern Conference matchup on Saturday, April 4.
Pistons vs 76ers prediction
Pistons vs 76ers best bet: Jalen Duren Over 34.5 points+rebounds (-120)
Jalen Duren earned his first All-Star appearance in 2025-26 behind averages of 19.5 points and 10.7 rebounds per game. Across his last 15 games, he’s averaging 34 points+rebounds, and across his last 11, those averages climb to 36.
The big man has hit for at 35+ points+rebounds in seven of his last 11, and he’s averaged 34.3 across his last four road games. In two games against the Philadelphia 76ers, Duren finished with 24 points and rebounds in 15 minutes in a blowout and 37 points and rebounds in 37 minutes.
He’ll be forced to handle more scoring and rebounding responsibilities tonight without Detroit Pistons superstar guard Cade Cunningham still on the shelf.
Cunningham’s absence bodes well for Duren’s statistical output. In 55 games played with Cunningham this season, Duren has averaged 29.2 points+rebounds in 27.7 minutes.
In 11 games without him, Duren averaged 35.1 points+rebounds and 31.1 minutes. Duren has posted at least 35 points+rebounds in seven of 11 games played without Cunningham.
Philadelphia’s defense hasn’t been impressive this season. The Sixers have given up the 12th-most points, 11th-most rebounds, fourth-most offensive rebounds, and sixth-most second-chance points. Philly’s 114.8 defensive rating ranks 17th.
With Joel Embiid still banged up, Duren could feast against Andre Drummond and Adem Bona down low. I’ll bank on another big game from Detroit’s go-to option tonight.
Pistons vs 76ers same-game parlay
Duren is poised for a monster game, but the 76ers can keep this one close at home if Tyrese Maxey goes off. Detroit is just 12-16 ATS as the road favorite, and Philly is 6-7 as the home dog.
I like Detroit to win this one outright, but I’m not betting the spread with uncertainty surrounding the statuses of Paul George and Joel Embiid.
Season-long trends lean the Under tonight, but both offenses have played well as of late. Detroit has combined for 227+ points in three of its last six games, and Philadelphia has reached that total in four of its last five.
Even without Cunningham and potentially without Embiid, there is enough firepower for both teams to put up points.
Pistons vs 76ers SGP
- Jalen Duren Over 34.5 points+rebounds
- Pistons moneyline
- Over 226.5
Our "from downtown" SGP: Guard-Play!
Tyrese Maxey has averaged 24.5 points and 8.5 assists in four games since returning from a lengthy absence. In that span, he hasn’t reached 29 points due to Paul George’s monster impact as a scorer.
With George potentially out tonight on the second leg of a back-to-back, Maxey could see far more work on offense. He’s also dished 7+ assists in four straight.
Daniss Jenkins has started nine straight games, averaging 19.3 points and seven dimes. In that span, he’s gone for 18+ points six times and 7+ assists five times. Expect another high-usage, highly-productive outing tonight with Cade Cunningham still sidelined.
Pistons vs 76ers SGP
- Daniss Jenkins Over 17.5 points
- Tyrese Maxey Over 28.5 points
- Daniss Jenkins Over 6.5 assists
- Tyrese Maxey Over 6.5 assists
Pistons vs 76ers odds
- Spread: Pistons -3.5 (-105) | 76ers +3.5 (-115)
- Moneyline: Pistons -160 | 76ers +135
- Over/Under: Over 226.5 | Under 226.5
Pistons vs 76ers betting trend to know
The Detroit Pistons have hit the Moneyline in 27 of their last 40 away games (+10.35 Units / 9% ROI). Find more NBA betting trends for Pistons vs. 76ers.
How to watch Pistons vs 76ers
| Location | Xfinity Mobile Arena, Philadelphia, PA |
| Date | Saturday, April 4, 2026 |
| Tip-off | 7:00 p.m. ET |
| TV | Detroit SportsNet, NBC Sports Philadelphia |
Pistons vs 76ers latest injuries
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