Even in a slightly underwhelming regular season, the Cleveland Cavaliers can hit the 50-win mark tonight as they visit the Memphis Grizzlies.
Memphis has dropped four straight and could boost its lottery odds with another loss here, so my Cavaliers vs. Grizzlies predictions expect Donovan Mitchell and James Harden to lead the onslaught at FedExForum.
Check out my NBA picks for this April 6 clash, with both squads on the second night of a back-to-back set.
Cavaliers vs Grizzlies prediction
Cavaliers vs Grizzlies best bet: Cavaliers -15.5 (-110)
The Cleveland Cavaliers would surely prefer to hang onto the No. 4 seed and avoid the Celtics-Knicks side of the East bracket, but they’re 8-2 straight up in their last 10 and heavy favorites to breeze past the Memphis Grizzlies tonight.
I’m riding with a Cleveland team that’s won the last six meetings with Memphis, and there’s every reason to expect that streak to continue, given the Grizzlies’ recent form. Three of the hosts’ past four losses have come by a margin of 15+ points, and Cedric Coward and GG Jackson both missed yesterday’s defeat in Milwaukee.
This is a lot of points to lay, especially after a sleepy Cavs win over the Pacers last night, but it’ll only take one quality stretch from Donovan Mitchell and James Harden to put this game on ice. The visitors may also have Evan Mobley and Jarrett Allen back to control the paint and paper over lapses on the perimeter.
The numbers point to the Cleveland offense as the difference-maker. The Cavs average 119.3 points per game, fueled by the seventh-most 3-pointers attempted, while the Grizzlies are giving up 119.7, the sixth-most in the league.
Memphis is 26-33 against the spread as an underdog, so I prefer to trust a Cleveland squad that’s 24-15 SU on the road and has Mitchell coming off a 38-point outburst.
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Cavaliers vs Grizzlies same-game parlay
Putting aside Harden’s playoff no-shows for a moment, he’s a regular-season winner, and I expect him to have his fingerprints all over a Cavs win today.
He averaged 8.1 assists in March, and he’s knocked down eight 3-pointers across his past two outings. If at least one of Mobley and Allen is available, those lob threats will boost The Beard’s dimes tally.
Cavaliers vs Grizzlies SGP
- Cavaliers -15.5
- James Harden Over 7.5 assists
- James Harden Over 2.5 made threes
Our "from downtown" SGP: The Mitchell Report
Mitchell is the key to a deep Cavs postseason run, and I love all the Overs for Spida tonight. He’s averaging 27.8 PPG, and he’s had six assists in two of his last three games. It’s hard to see Memphis keeping him out of the paint here.
Cavaliers vs Grizzlies SGP
- Cavaliers -15.5
- Donovan Mitchell Over 25.5 points
- Donovan Mitchell Over 2.5 made threes
- Donovan Mitchell Over 5.5 assists
Cavaliers vs Grizzlies odds
- Spread: Cavaliers -15.5 (-110) | Grizzlies +15.5 (-110)
- Moneyline: Cavaliers -1600 | Grizzlies +900
- Over/Under: Over 234.5 (-110) | Under 234.5 (-110)
Cavaliers vs Grizzlies betting trend to know
The Grizzlies are 1-9 SU in their last 10 contests. Find more NBA betting trends for Cavaliers vs. Grizzlies.
How to watch Cavaliers vs Grizzlies
| Location | FedExForum, Memphis, TN |
| Date | Friday, April 6, 2026 |
| Tip-off | 8:00 p.m. ET |
| TV | FDSN-Ohio, FDSN-Memphis |
Cavaliers vs Grizzlies latest injuries
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