The Cleveland Cavaliers have started the 2025-26 campaign on fire, and they'll look to keep the good times rolling against the Boston Celtics.
My Cavaliers vs. Celtics predictions think Cleveland will leave Boston undefeated.
Read on for a full breakdown of this Eastern Conference matchup in my free NBA picks for Wednesday, October 29.
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Cavaliers vs Celtics prediction
Cavaliers vs Celtics best bet: Cavaliers -3.5 (-110 at bet365)
Last season, the Cleveland Cavaliers and Boston Celtics dueled for the top position in the Eastern Conference heading into the playoffs.
But that’s unlikely to be the case again this year, as Boston will spend at least a large portion of the season without Tatum in the lineup after he suffered a ruptured Achilles tendon during the playoffs against the New York Knicks.
So far, the Celtics haven’t found a way to look like a contender without their star. Jaylen Brown (26.0 ppg) has picked up much of the scoring slack, but the loss of Tatum and Kristaps Porzingis has left this roster looking dangerously thin compared to last season.
Even Brown is dealing with his own hamstring issue and is likely not yet at 100%, playing 24 minutes and scoring just 15 points on Monday against the New Orleans Pelicans.
On the other hand, Cleveland looks set for another big season after last year’s incredible turnaround under Kenny Atkinson. Donovan Mitchell (31.3 ppg) and Evan Mobley (18.3 ppg) have led the Cavs to three straight wins after a season opening loss to the Knicks, and they should roll again tonight.
I’m taking Cleveland to cover.
Cavaliers vs Celtics same-game parlay
Both teams have been playing to relatively low totals, with the Celtics in particular playing to a slow pace, which has me looking at the Under tonight.
I’ll round out the SGP by taking Evan Mobley to hit his PRA total, as he’s put up a combined average of 34.4 so far this season.
Cavaliers vs Celtics SGP
- Cavaliers -3.5
- Under 233.5
- Evan Mobley Over 32.5 points + rebounds + assists
Our "from downtown" SGP: Mitchell pours it on C's
Mitchell is averaging 31.3 ppg and has gone for 30+ in three of his first four games – including two that were played to totals below tonight’s number.
Cavaliers vs Celtics SGP
- Cavaliers -3.5
- Under 233.5
- Evan Mobley Over 32.5 PRA
- Donovan Mitchell Over 29.5 points
Cavaliers vs Celtics odds
- Spread: Cavaliers -3.5 (-110) | Celtics +3.5 (-110)
- Moneyline: Cavaliers -170 | Celtics +145
- Over/Under: Over 234 (-110) | Under 234 (-110)
Cavaliers vs Celtics betting trend to know
The Cavaliers are 5-1 ATS in their last six meetings with the Celtics. Find more NBA betting trends for Cavaliers vs. Celtics.
How to watch Cavaliers vs Celtics
| Location | TD Garden, Boston, MA |
| Date | Wednesday, October 29, 2025 |
| Tip-off | 7:00 p.m. ET |
| TV | ESPN |
Cavaliers vs Celtics latest injuries
Not intended for use in MA.
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