The New York Yankees will try to complete a road sweep of the Boston Red Sox tonight behind the electric Cam Schlittler.
My Yankees vs. Red Sox predictions believe Boston righty Payton Tolle is completely outmatched, and my MLB picks will take the Bombers moneyline on Thursday, April 23.
Who will win Yankees vs Red Sox today: Yankees moneyline (-143)
I’ve tried to find a scenario where the Boston Red Sox should be less than a +150 underdog to avoid the sweep against New York Yankees righty Cam Schlittler, and I just can’t get there. I’d play this to around -160.
Schlittler threw eight scoreless innings and registered 12 strikeouts against his boyhood team in last year's postseason.
Schlittler's most thrown pitch, the fastball, has been one of the best pitches in baseball, ranking in the 100th percentile of run value.
Boston righty Payton Tolle, meanwhile, is walking over 10% of batters he faces and is carrying a 4.70 xERA.
New York shouldn’t need to score much to get the win.

Yankees vs Red Sox Over/Under pick: Under 8.5 (-120)
I’m not sure this one looks much different from yesterday when Max Fried threw eight scoreless innings in a near-shutout win. I’ll back the Under here with a projected total of 8.1.
This Under lives and dies with Schlittler, and I'm fine with that. He’ll get plenty of chase, as Boston’s Top 7 whiff rate and Bottom 7 chase contact rate looms large..
Tolle's command issues could let the Yankees get to four or five runs, but this still doesn't feel like an eight-run ballgame.
- ML/RL bets: 7-6, +0.92 units
- Over/Under bets: 8-6, +2 units
Yankees vs Red Sox odds
- Moneyline: Yankees -150 | Red Sox +130
- Run line: Yankees -1.5 | Red Sox +1.5
- Over/Under: Over 8.5 | Under 8.5
Yankees vs Red Sox trend
The Red Sox have hit the Under in 24 of their last 40 games at home (+7.35 Units / 17% ROI). Find more MLB betting trends for Yankees vs. Red Sox.
How to watch Yankees vs Red Sox and game info
| Location | Fenway Park, Boston, MA |
| Date | Thursday, April 23, 2026 |
| First pitch | 6:10 p.m. ET |
| TV | FS1 |
| Yankees starting pitcher | Cam Schlittler (2-1, 1.95 ERA) |
| Red Sox starting pitcher | Payton Tolle (0-1, 6.06 ERA) |
Yankees vs Red Sox latest injuries
Yankees vs Red Sox weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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