White Sox vs Twins Prediction, Picks, and Odds for Tonight’s MLB Game

The Twins and White Sox have gotten off to horrendous starts to the season, but our MLB picks explain why we believe Chicago will suck just a bit less than Minnesota tonight.

Apr 22, 2024 • 15:42 ET • 4 min read
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This article contains predictions for an old game!

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Jonathan Cannon Chicago White Sox MLB
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Two teams that are struggling to find wins will face off tonight as the Minnesota Twins host the Chicago White Sox for the start of a four-game series. 

Minnesota won just one of its last seven games but is still favored over lowly Chicago, who is just 1-9 in its last 10. 

With both teams desperately needing to turn things around, I’ll break down this matchup for bettors in my White Sox vs Twins picks for April 22 — providing you with my favorite MLB picks.

White Sox vs Twins prediction

My best bet
White Sox moneyline (+180 at Caesars)

My analysis

The Chicago White Sox have been the worst team in the majors this year. Not only do they have the worst record in the league, but their run differential of -71 is 16 runs worse than the next-lowest team (the Colorado Rockies). 

Chicago’s biggest problem has been scoring. Somehow, the White Sox have only 45 runs for the entire season after 21 games, a pathetic average of just 2.14 per outing.

Chicago has at least seen some offense peak out in its last two games, scoring a grand total of seven runs against the Philadelphia Phillies over the weekend. Having Eloy Jimenez back from his adductor injury seems to have helped a bit, as any lengthening of the lineup will make a huge impact right now.

Thankfully for the White Sox, the Minnesota Twins haven’t been much better. Minnesota is averaging just 3.35 runs per game and holds the third-worst record in the American League. 

Tonight, Minnesota will send Chris Paddack to the mound. Paddack has struggled to stay healthy over the last few years, missing most of 2023 due to recovery from Tommy John surgery. As a result, he's only made eight starts over the last three seasons. 

Paddack has never been a frontline starter in the majors, going just 22-22 with a 4.38 ERA for his career, one that has spanned just 349.1 innings of work over six seasons. He also hasn’t looked great for Minnesota so far in 2024, putting up an 8.36 ERA over 14 innings of work in his first three starts. In his last outing, the Orioles hit him for nine runs on 12 hits over 5 1/3 innings.

It would be stunning if the White Sox could do that much work against him, but chances are they’ll be able to put up a few runs. And with 23-year-old rookie Jonathan Cannon on the mound for Chicago — who went five innings and allowed just one run in his first career start last week against the Royals — Chicago has a starter who could confound an underwhelming Twins lineup.

Chicago is still the underdog in this game, but the moneyline — especially after bettors moved it significantly in Minnesota’s direction — is way off. If the White Sox can win any game, it’s this one tonight. I’m taking them on the moneyline to pull off the upset.

White Sox vs Twins same-game parlay (SGP)

White Sox moneyline

Over 8.5

Eloy Jiminez to record a hit

The White Sox have value tonight because their offense should finally have some success against Paddack. That’s why I also like the Over tonight for a same-game parlay.

We can also include a bet on Eloy Jimenez to get a hit. While Jimenez is hitting just .167 on the year, he has three hits in the last two games and looks to finally be finding his rhythm at the plate. 

Learn how to bet a same-game parlay with these helpful tips and strategies.

White Sox vs Twins odds

White Sox vs Twins live odds

White Sox vs Twins opening odds

  • Run line: Chicago +1.5 (-139) | Minnesota -1.5 (+126)
  • Moneyline: Chicago +154 | Minnesota -168
  • Over/Under: Over 8.0 (-112) | Under 8.0 (+100)

White Sox vs Twins spread and Over/Under analysis

  • The Twins opened as a -168 favorite over the White Sox. That moneyline has lengthened considerably, with Minnesota -205 now the approximate consensus line. 
  • The Twins have lost more than seven units on the moneyline this year, while Chicago has been even worse, dropping nearly 13 units for bettors on the season.
  • The total for tonight’s game opened at eight runs flat. Most books have since moved to 8.5 runs, with the Over available at +100 odds at some sites. 
  • The Under holds a 12-8 edge in White Sox games this year and also has an 11-8 record when the Twins play.

White Sox vs Twins trend

The Twins are 1-6 overall in their last seven games. Find more MLB betting trends for White Sox vs. Twins

White Sox vs Twins game info

Location: Target Field, Minneapolis, MN
Date: Monday, 4-22-2024
First pitch: 7:40 p.m. ET
TV: Bally Sports North, NBCS-Chicago
White Sox starting pitcher: Jonathan Cannon
(0-0, 1.80 ERA)
Twins starting pitcher: Chris Paddack
(0-1, 8.36 ERA)

White Sox vs Twins latest injuries

White Sox vs Twins weather

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