The Cincinnati Reds and Pittsburgh Pirates begin a three-game set tonight at PNC Park, with the Bucs looking to end a five-game skid.
However, my Reds vs. Pirates predictions are eyeing Cincy to grab a win behind right-hander Brady Singer, who has been much better lately.
Read more for my MLB picks for Friday, May 1.
Who will win Reds vs Pirates today: Reds moneyline (+116)
The Cincinnati Reds will send Brady Singer to the hill tonight, and he’s held the Pittsburgh Pirates lineup to a .234 average across 77 at-bats. Singer has also allowed three runs or fewer in each of his last three starts. In his last road outing, the righty allowed three earned to the Minnesota Twins across six innings of work.
The Bucs are hitting just .244 against right-handers, and they’ve dropped five games in a row. Pittsburgh was just swept at home by the St. Louis Cardinals. Mitch Keller has given up seven earned runs across his last two outings at PNC Park.
While he’s held the Reds to a .220 average in 118 at-bats, Cincy is playing good baseball right now, and their 10-3 road record is very impressive. The Pirates are just 8-9 at home.
COVERS INTEL: Mitch Keller has struggled in night games, posting an 8.00 ERA across two starts.
Reds vs Pirates Over/Under pick: Over 8.5 runs (+100)
Both starters have pitched quite well lately, giving their respective teams a chance to win. However, neither has been completely lights out, and both bullpens have been shaky over the last week, giving up numerous runs in the middle and late innings.
Also, the Over has comfortably hit in back-to-back meetings, with both games finishing 8-3. The Bucs were atrocious on the hill against the Cardinals, allowing 10 or more runs in two of the three contests – at home.
The Reds are a very good team on the road, and whether it’s against Keller, the Pittsburgh bullpen, or both, they will add to the Pirates’ misery with a solid offensive performance.
- ML/RL bets: 9-9, -4.45 units
- Over/Under bets: 10-8, 0.48 units
Reds vs Pirates odds
- Moneyline: Cincinnati +114 | Pittsburgh -126
- Run line: Cincinnati +1.5 (+183) | Pittsburgh -1.5 (+158)
- Over/Under: Over 8.5 (+101) | Under 8.5 (-116)
Reds vs Pirates trend
The Cincinnati Reds have hit the Moneyline in 10 of their last 13 away games (+8.65 Units / 66% ROI). Find more MLB betting trends for Reds vs. Pirates.
How to watch Reds vs Pirates and game info
| Location | PNC Park, Pittsburgh, PA |
| Date | Friday, May 1, 2026 |
| First pitch | 6:45 p.m. ET |
| TV | Apple TV |
| Reds starting pitcher | Brady Singer (2-1, 4.97 ERA) |
| Pirates starting pitcher | Mitch Keller (2-1, 3.18 ERA) |
Reds vs Pirates latest injuries
Reds vs Pirates weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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