Guardians vs Rays Home Run Predictions & Combo: ALCS Game 6

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst 16+ years betting experience
Updated: Oct 19, 2026 , 12:27 PM ET • 4 min read

Tampa slugger Junior Caminero headlines tonight's Guardians vs. Rays home run predictions and MLB picks for Game 6 of the ALCS.

Guardians vs Rays Home Run Picks, Tampa Bay Rays, MLB, Junior Caminero
Photo By - Reuters Connect. Tampa Bay Rays infielder Junior Caminero at Progressive Field during the 2026 ALCS.

The Tampa Bay Rays can punch their ticket to the World Series with a Game 6 win over the Cleveland Guardians at Tropicana Field on Monday, Oct. 19.

Tampa is the favorite ahead of the 8 p.m. first pitch, and star Junior Caminero headlines my favorite Guardians vs. Rays home run predictions and MLB picks for Game 6 tonight.

Meanwhile, Chris Hatfield expects the Rays to advance in his Guardians vs. Rays predictions.

Best Guardians vs Rays home run picks

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Pick Probability
 Guardians Chase DeLauter 10%
 Rays Junior Caminero 19%
 Guardians Long shot: Travis Bazzana 10%
💲HR combo 476x
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Guardians home run pick: Chase DeLauter

Tampa Bay Rays righty Freddy Peralta surrendered a healthy 1.42 HR/9 to left-handed hitters during the regular season, and Cleveland Guardians outfielder Chase DeLauter has posted a rock-solid 43.5% hard-hit rate and 16.7% blast-contact rate against righties this postseason. 

Of course, Peralta’s 0.79 ERA across three playoff appearances is also miles below his 4.04 xERA and 5.37 xFIP.

Rays home run pick: Junior Caminero

Rays slugger Junior Caminero posted a solid .204 ISO against lefties and a .264 mark against righties during the regular season. Because Cleveland is going with a full bullpen game, I'm targeting his balanced platoon splits.

Caminero has also been limited to five singles through the first five games of the series despite a solid 44.4% hard-hit rate and 20.0% blast-contact rate, so he’s a go-to candidate to leave the yard tonight. 

Long-shot home run pick: Travis Bazzana

Guardians rookie Travis Bazzana hit 13 of his 15 regular-season homers against righties with a .211 ISO. He’s also recorded a respectable .220 xISO this postseason alongside a 38.5% hard-hit rate and 15.1% blast-contact rate, so Bazzana has been dialed in at the dish.

As noted, Peralta has statistical correction ahead, and he’s allowed a healthy 15.4 barrel rate to left-handed hitters in the playoffs.

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Guardians vs Rays home run combo

With a game total of just 6.5 and only six home runs through the first five games of the ALCS, expectations of connecting on a three-leg, home-run combo should be held in check.

Still, Peralta gave up multiple homers six times during the regular season, and his 41.9% fly-ball rate was the 13th-highest mark among qualified starters.

All three hitters have solid underlying numbers dating back to the regular season, too.

Neil Parker's 2026 Transparency Record
  • HR picks: 0-0, 0 units
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs at some of the top websites in the industry.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

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