Pirates vs Brewers Prediction, Picks & Odds for Today’s MLB Game

The matchup between Paul Skenes and Jacob Misiorowski is appointment viewing, but books have set the total at 6.5. This is dicey, especially considering Misiorowski's inexperience and both bullpens' volatility.

Eric Rosales - Contributor at Covers.com
Eric Rosales • Betting Analyst
Jun 25, 2025 • 08:23 ET • 4 min read

MLB

Match starts: 4 mins
MIL
52 %
PIT
48 %
EXPERT PICK - TOTAL
o6.5 (-110)
Read Analysis
Paul Skenes Pittsburgh Pirates MLB
Photo By - Imagn Images. Pirates ace Paul Skenes throws a pitch during MLB action.

The Milwaukee Brewers bounced back from a 5-4 loss in the opener against the Pittsburgh Pirates to take Game 2 on Tuesday, making it five wins in their last six.

With an exceptional pitching matchup on tap, our Pirates vs Brewers predictions and MLB picks are taking the bait on an unusually low total for Wednesday, June 25.

Pirates vs Brewers prediction

My Pirates vs Brewers best bet: Over 6.5 (-110 at BetMGM)

Pirates vs Brewers same-game parlay (SGP)

Over 6.5

Paul Skenes Over 7.5 strikeouts

Pirates team total Over 2.5

Pirates vs Brewers odds

Pirates vs Brewers live odds

Pirates vs Brewers opening odds

  • Moneyline: Pittsburgh -115 | Milwaukee -105
  • Run line: Pittsburgh -1.5 (+150) | Milwaukee +1.5 (-180)
  • Over/Under: Over 7 (+100) | Under 7 (-120)

Pirates vs Brewers trend

Milwaukee has won four straight as a betting underdog. Find more MLB betting trends for Pirates vs. Brewers.

How to watch Pirates vs Brewers and game info

Location American Family Field, Milwaukee, WI
Date Wednesday, 6-25-2025
First pitch 2:10 p.m. ET
TV SNP, FDSN
Pirates starting pitcher Paul Skenes
(4-6, 1.85 ERA)
Brewers starting pitcher Jacob Misiorowski
(2-0, 1.64 ERA)

Pirates vs Brewers latest injuries

Pirates vs Brewers weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Eric Rosales - Covers
Betting Analyst

Eric has been involved in sports media in many different capacities since graduating from journalism school in 1999, back when getting your own column in a newspaper was still considered a thing. He doubled down and graduated from broadcast journalism school five years later, which led to a move to Toronto and a career with The Sports Network (TSN). From behind-the-scenes production work, he moved into the digital realm, where he had his own hoops column (At the Buzzer), while regularly live streaming and chatting with fans during broadcasts as the character known as LeBlog James. He was also a key contributor to TSN and CTV’s Olympic programming during the 2012 London Games.

Eric eventually found his way into the sports betting field in 2016 and has been a mainstay ever since. He was tagged on Twitter as a Top 10 NBA sharp during the 2021 season and has been interviewed about basketball and his handicapping process on shows from Vancouver to India. Eric is now a jack-of-all-sports at Covers, where his predictions span the alphabet soup: NFL, NBA, MLB, NHL, F1, WNBA, Euro, and Copa.

When making picks, he focuses on finding value first and foremost, and ensuring readers have all the information they need to make an informed choice.

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