The Philadelphia Phillies lost to the Chicago Cubs on April 14, and the Phillies have dropped another seven straight since while the Cubbies haven't lost.
Wrigley Field will play host to their series finale on Thursday, April 23, and my top Phillies vs. Cubs predictions and MLB picks are calling for the North Siders to fly the W and hand Philly a ninth consecutive loss.
Who will win Phillies vs Cubs today: Cubs moneyline (+107)
The Philadelphia Phillies have lost eight straight while scoring just 16 total runs.
I’m confident starter Cristopher Sanchez (1.59 ERA and 2.21 xFIP) will pitch well, but the Chicago Cubs are cruising along on an eight-game winning streak while averaging 7.25 runs per game. They also rank second in wOBA against lefties for the year.
Chicago starter Edward Cabrera has been effective with a 2.38 ERA. His 4.32 xFIP and 4.24 xERA highlight he’s overachieving, but as noted, the Philadelphia lineup is scuffling and ranks last in wOBA during the highlighted skid.
COVERS INTEL: Cabrera has limited opposing hitters to a miniscule .282 SLG and .285 wOBA through 22 2/3 innings.
Phillies vs Cubs Over/Under pick: Under 9.5 (-139)
While the wind is forecasted to be blowing out to right field on Thursday afternoon, the highlighted struggles of the Philly lineup paired with Sanchez’s dominant 31.7 K% and 59.2% ground-ball rate point me to the Under.
This is also a getaway game, and both the Phillies and Cubs play road games Friday. I don’t expect Sanchez or Cabrera to face the toughest lineups their opponents can send to the dish here.
- ML/RL bets: 7-7, +0.51 units
- Over/Under bets: 4-4, -0.47 units
Phillies vs Cubs odds
- Moneyline: Phillies -113 | Cubs +108
- Run line: Phillies -1.5 (+144) | Cubs +1.5 (-150)
- Over/Under: Over 9.5 (+113) | Under 9.5 (-117)
Phillies vs Cubs trend
The Cubs have won each of their last eight games (+8.40 Units / 82% ROI). Find more MLB betting trends for Phillies vs. Cubs.
How to watch Phillies vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Thursday, April 23, 2026 |
| First pitch | 2:20 p.m. ET |
| TV | NBCS-Philadelphia, Marquee |
| Phillies starting pitcher | Cristopher Sancez (2-2, 1.59 ERA) |
| Cubs starting pitcher | Edward Cabrera (2-0, 2.38 ERA) |
Phillies vs Cubs latest injuries
Phillies vs Cubs weather
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