The Cleveland Guardians look to finish a four-game sweep and push their winning streak to six when they visit the Detroit Tigers at Comerica Park this afternoon.
I’ll break down why I’m taking the visitors to break out the brooms in my Guardians vs. Tigers predictions and MLB picks for Thursday, May 21.
Who will win Guardians vs Tigers today: Guardians moneyline (+100)
The Cleveland Guardians come into the series finale as a slight underdog, but there’s plenty to like about the visitors in this matchup.
The Detroit Tigers are banged up, missing three starters in Gleyber Torres, Javier Baez, and Kerry Carpenter. Unsurprisingly, Detroit is 2-13 over its last 15 contests while mustering a mere 2.47 runs per game through that span.
The Guardians, meanwhile, are 8-1 over their last nine, ranking second in runs scored (102) and third in on-base percentage (.347) among all teams this month.
COVERS INTEL: The Tigers are hitting .215 vs. left-handed pitching, the third-worst mark in the majors. Not ideal with Joey Cantillo on the bump for Cleveland.
Guardians vs Tigers Over/Under pick: Under 7.5 (-125)
Detroit has a dismal offense, but also a solid starter on the hill today in Casey Mize.
Mize, who has allowed one earned run or fewer in five of seven starts, carries a stingy 2.43 ERA and ranks in the 85th percentile in xBA (.211).
The Tigers can’t score, Mize won’t give up a ton, and both teams have bullpens with a sub-4.00 ERA. That all adds up to a third straight meeting with Under 7.5 runs.
- ML/RL bets: 1-0, +0.67 units
- Over/Under bets: 0-1, -1 unit
Guardians vs Tigers odds
- Moneyline: Guardians +108 | Tigers -113
- Run line: Guardians -1.5 (+178) | Tigers +1.5 (-186)
- Over/Under: Over 7.5 (+117) | Under 7.5 (-122)
Guardians vs Tigers trend
Detroit has cashed the Under in five of its last six games. Find more MLB betting trends for Guardians vs. Tigers.
How to watch Guardians vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Thursday, May 21, 2026 |
| First pitch | 1:10 p.m. ET |
| TV | Guardians.TV, DSN |
| Guardians starting pitcher | Joey Cantillo (3-1, 3.40 ERA) |
| Tigers starting pitcher | Casey Mize (2-2, 2.43 ERA) |
Guardians vs Tigers latest injuries
Guardians vs Tigers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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