Cubs vs Cardinals Prediction, Picks & Odds for Tonight’s MLB Game

Parker's prediction: Erick Fedde has struggled to pitch deep into games this season, and his start against the Cubs will be no different.

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst
Jun 25, 2025 • 16:33 ET • 4 min read
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This article contains predictions for an old game!

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Erick Fedde St. Louis Cardinals MLB
Photo By - Imagn Images. St. Louis Cardinals pitcher Erick Fedde (12) pitches during the second inning.

The St. Louis Cardinals have drawn first blood in their four-game series against the Chicago Cubs, taking the opening two matchups. Now, the NL Central rivals return to Busch Stadium for Game 3 tonight.

St. Louis hands the ball to right-hander Erick Fedde, but based on recent trends and matchups, our Cubs vs. Cardinals predictions sees limited innings in his future.

Find out why in my MLB picks for June 25.

Cubs vs Cardinals prediction

My Cubs vs Cardinals best bet: Erick Fedde Under 17.5 outs recorded (-130 at DraftKings)

Cubs vs Cardinals same-game parlay (SGP)

Cubs -1.5

Michael Busch 1+ RBI

Erick Fedde Over 1.5 walks issued

Cubs vs Cardinals odds

Cubs vs Cardinals live odds

Cubs vs Cardinals opening odds

  • Moneyline: Chicago -125 | St. Louis +105
  • Run line: Chicago -1.5 (+130) | St. Louis +1.5 (-155)
  • Over/Under: Over 9 (+100) | Under 9 (-120)

Cubs vs Cardinals trend

The Chicago Cubs have won 44 of their last 73 games (+8.95 Units / 8% ROI). Find more MLB betting trends for Cubs vs. Cardinals.

How to watch Cubs vs Cardinals and game info

Location Busch Stadium, St. Louis, MO
Date Wednesday, 6-25-2025
First pitch 7:45 p.m. ET
TV MARQ, FDSN
Cubs starting pitcher Matthew Boyd
(6-3, 2.84 ERA)
Cardinals starting pitcher Andre Pallante
(5-3, 4.48 ERA)

Cubs vs Cardinals latest injuries

Cubs vs Cardinals weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs at some of the top websites in the industry.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

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