Nolan Arenado looked like he was on his way out of town after a down season, but the veteran St. Louis Cardinals third baseman will take his hacks against the Baltimore Orioles tonight.
My Cardinals vs. Orioles predictions are bullish on Nado's bat coming through in the clutch.
I explain why it's always a good time to fade Baltimore pitching with my MLB picks on Wednesday, May 28.
Cardinals vs Orioles prediction
My Cardinals vs Orioles best bet: Nolan Arenado Over 1.5 hits+runs+RBI (+100 at BetMGM)
St. Louis Cardinals third baseman Nolan Arenado is no longer the perennial MVP candidate he once was. He's an eight-time All-Star and one of the best defensive MLB third basemen in recent memory. He's a fringe Hall-of-Fame candidate even if he hung up his cleats today.
The last couple of seasons haven't been kind to his offense, and after a solid start to 2025, he's cooled down, slashing .238/.308/.394 with six home runs in 50 games.
However, the Cardinals are playing the Baltimore Orioles, who are becoming everyone's favorite punching bag this season.
Baltimore's pitching, particularly in the rotation, has been abominable. Only the Rockies (5.66) have a worse team ERA than the Orioles (5.50) and no team has allowed more home runs than the 86 Baltimore has let fly. What can you expect when you replace ace Corbin Burnes with the withered Charlie Morton?
Today, the Orioles turn to sophomore lefty Cade Povich. The 25-year-old built himself up as a high-profile prospect, but the success hasn't translated to the big leagues. This season, he's 1-3 with a 4.86 ERA and 1.45 WHIP while allowing eight home runs in 46 1/3 innings.
Right-handed bats have especially throttled him, slashing .288/.355/.464. He's also fared much worse at home, where he's watched seven of those eight homers leave the ballpark — leaving him with a 6.75 ERA at Camden Yards.
Baltimore moved the left-field fence back in a bit this year after the park saw a downturn in right-handed power. Well, it might be backfiring as opposing bats are taking advantage. Arenado himself went deep just last night as he went 2-for-5 in the Cardinals' victory.
He might not go deep again, but he still sees lefty pitching well, as evidenced by his .292 average against southpaws in 2025 (not far off his career mark of .297). And if Povich gives way to the bullpen early, Orioles relievers have a collective 5.45 ERA (fourth-highest in MLB).
Arenado can clear this early, too. He's been hitting lower in the order of late (typically sixth) but St. Louis doesn't have a ton of thump ahead of him. The Cardinals tend to string together hits, clog up basepaths, and score their runs by passing the baton.
Cardinals vs Orioles same-game parlay (SGP)
Nolan Arenado Over 1.5 H+R+RBI
Jordan Walker 2+ total bases
Cardinals moneyline
BetMGM doesn't offer the H+R+RBI market in their SGPs, so we're taking slightly worse odds on Arenado's Over 1.5 to combine it with some other strong options.
Outfielder Jordan Walker has largely disappointed in his big-league career, but his bat speed is elite and his average exit velocity when he makes contact ranks among baseball's best. It's all about squaring it up, making consistent contact, and not drilling it into the ground.
Things may be starting to turn. Despite the small sample, Walker has three multi-hit games in his last four. With right-handed bats tormenting Povich, this is another key matchup for Walker (who is still only 23).
As we continue to fade Baltimore's pitching, we are also giving the Cardinals a little credit. This team is seven games above .500 and has consistently proven resilient.
Cardinals vs Orioles odds
Cardinals vs Orioles live odds
Cardinals vs Orioles opening odds
- Moneyline: St. Louis +100 | Baltimore -120
- Run line: St. Louis +1.5 (-190) | Baltimore -1.5 (+160)
- Over/Under: Over 8.5 (-120) | Under 8.5 (+100)
Cardinals vs Orioles trend
The Baltimore Orioles have only hit the moneyline in 16 of their last 49 games (-24.35 Units / -41% ROI). Find more MLB betting trends for Cardinals vs. Orioles.
How to watch Cardinals vs Orioles and game info
| Location | Oriole Park at Camden Yards, Baltimore, MD |
| Date | Wednesday, 5-28-2025 |
| First pitch | 6:35 p.m. ET |
| TV | FanDuel Sports Network Midwest, MASN |
| Cardinals starting pitcher | Miles Mikolas (4-2, 3.51 ERA) |
| Orioles starting pitcher | Cade Povich (1-3, 4.86 ERA) |
Cardinals vs Orioles latest injuries
Cardinals vs Orioles weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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