Trey Yesavage baffled New York Yankees batters in his lone career outing against them in the playoffs last October, and I expect another strikeout-filled outing for the Toronto Blue Jays starter tonight.
Read on to see why with my Blue Jays vs. Yankees predictions and MLB Picks on Wednesday, May 20.
Blue Jays vs Yankees predictions
Blue Jays vs Yankees best bet: Trey Yesavage Over 5.5 strikeouts (-140)
Toronto Blue Jays right-hander Trey Yesavage has picked up right where he left off last postseason, as one of the hardest pitchers to hit in baseball.
He’s got a 1.40 ERA with 21 strikeouts in just four appearances, going Over tonight’s 5.5 posted total in three straight, largely thanks to a 90th-percentile whiff rate.
I’ll bet on him doing it for a fourth straight game tonight in a matchup that favors him immensely.
The New York Yankees own the seventh-worst strikeout rating in all of baseball, with the fifth-worst against the splitter, specifically.
Additionally, Yesavage has just one career start against the Yankees where he went 5 1/3 innings of hitless baseball with 11 Ks.
COVERS INTEL: Yesavage ranks in the 97th percentile with a .162 xBA.
Blue Jays vs Yankees same-game parlay (SGP)
I’ll continue to ride with Yesavage for the second leg on my SGP and take Under 2.5 earned runs allowed. He’s been Under that number in all four of his starts this season. He also limits hard contact, respectively ranking in the 88th and 99th percentiles in barrel and hard-hit rates.
For the final leg of my SGP, I’ll take Daulton Varsho to go Over 0.5 hits tonight. He’s heating up with hits in four straight, totaling nine in that stretch. He’s also 1-for-4 lifetime against Cam Schlittler.
Blue Jays vs Yankees SGP
- Trey Yesavage Over 5.5 strikeouts
- Trey Yesavage Under 2.5 earned runs
- Daulton Varsho Over 0.5 hits
Blue Jays vs Yankees home run pick: Daulton Varsho (+405)
This will be a half-unit wager as Schlittler has only surrendered two home runs this season.
However, he does give up some hard contact, ranking in the 42nd percentile in opponent hard-hit rate.
Varsho owns a 60% hard-hit rate against the four-seam fastball, which Schlittler uses most often against lefties.
Yankee Stadium is a hitters' park, so if Varsho gets hold of one over the plate, he will take it for a ride.
- Best bets: 21-26, +1.55 units
- SGPs: 8-39, -5.2 units
- HR picks: 8-39, +3.65 units
Blue Jays vs Yankees odds
- Moneyline: Toronto +150 | New York -175
- Run line: Toronto +1.5 (-140) | New York -1.5 (+120)
- Over/Under: Over 7.5 (-110) | Under 7.5 (-110)
Blue Jays vs Yankees trend
The Toronto Blue Jays have hit the Team Total Under in 15 of their last 23 away games (+6.40 Units / 24% ROI). Find more MLB betting trends for Blue Jays vs. Yankees.
How to watch Blue Jays vs Yankees and game info
| Location | Yankee Stadium, Bronx, NY |
| Date | Wednesday, May 20, 2026 |
| First pitch | 7:05 p.m. ET |
| TV | Sportsnet ONE, Amazon Prime Video |
| Blue Jays starting pitcher | Trey Yesavage (1-1, 1.40 ERA) |
| Yankees starting pitcher | Cam Schlittler (6-1, 1.35 ERA) |
Blue Jays vs Yankees latest injuries
Blue Jays vs Yankees weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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