Read on to see why with my Blue Jays vs. Yankees predictions and MLB Picks tonight.
Blue Jays vs Yankees predictions
Blue Jays vs Yankees best bet: Vladimir Guerrero Jr. Over 1.5 total bases (+130)
Vladimir Guerrero Jr. has a hit in three of his last four games, and a matchup against Carlos Rodon should give him confidence to stay consistent in the batter's box tonight.
He’s 11-for-18 with five extra-base hits and a 1.807 OPS against Rodon with five additional walks.
Furthermore, Rodon has had a tough start this season with a 5.63 ERA, allowing five runs in just eight innings of work.
The Yankees veteran is also throwing his four-seamer at a 40% rate, which plays into Vladdy’s strengths, who owns a .333 average and a .500 slug against the pitch.
COVERS INTEL: Guerrero owns a .303 career batting average with a .974 OPS at Yankee Stadium.
Blue Jays vs Yankees same-game parlay (SGP)
Dalton Varsho is riding a five-game hit streak with 10 total in that stretch. He’s also 3-for-8 with a .944 career OPS against Rodon. I’ll add Varsho to go Over 0.5 hits tonight.
Rodon is still trying to find his footing after missing the first six weeks of the season. He’s winless with a 5.63 ERA, allowing 2+ runs per start. He also owns a career 4.72 ERA against Toronto, allowing an .836 opponent OPS. I think the Jays find a way to put up runs tonight and take Over 1.5 earned runs for Rodon.
Blue Jays vs Yankees SGP
- Vladimir Guerrero Jr. Over 1.5 total bases
- Daulton Varsho Over 0.5 hits
- Carlos Rodon Over 1.5 earned runs
Blue Jays vs Yankees home run pick: Vladimir Guerrero Jr. (+475)
This will be a half-unit wager as Rodon doesn’t allow hard contact and has yet to allow a homer through two outings this season.
However, Guerrero has had Rodon’s number throughout his career with a pair of homers and five total extra-base hits in 18 plate appearances, posting a 1.807 OPS against him.
- Best bets: 22-26, -0.55 units
- SGPs: 3-39, -2.4 units
- HR picks: 8-4, +3.15 units
Blue Jays vs Yankees odds
- Moneyline: Toronto +125 | New York -145
- Run line: Toronto +1.5 (-160) | New York -1.5 (+140)
- Over/Under: Over 8 (-120) | Under 8 (+100)
Blue Jays vs Yankees trend
The Blue Jays have stayed Under their team total in 16 of their last 24 road games for +7.40 units and a 24% ROI. Find more MLB betting trends for Blue Jays vs. Yankees.
How to watch Blue Jays vs Yankees and game info
| Location | Yankee Stadium, Bronx, NY |
| Date | Thursday, May 21, 2026 |
| First pitch | 7:05 p.m. ET |
| TV | SN1, YES |
| Blue Jays starting pitcher | Braydon Fisher (2-1, 3.08 ERA) |
| Yankees starting pitcher | Carlos Rodon (0-1, 5.63 ERA) |
Blue Jays vs Yankees latest injuries
Blue Jays vs Yankees weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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