After cashing our best bet and same-game parlay yesterday, we're back with my Blue Jays vs. Yankees prediction for Friday night.
The Toronto Blue Jays will be in tough today as they navigate a bullpen day against the New York Yankees and Cam Schlittler, but I think their offense can help keep it close.
Let’s dive into my MLB picks for August 21, and fatten that wallet before the weekend.
Blue Jays vs Yankees predictions
Blue Jays vs Yankees best bet: Blue Jays team total Over 2.5 (-125)
Don't look now, but this Toronto Blue Jays offense is hummin', and has gone Over this total in six straight games.
It's a different offense than it was the last time the Jays took on the New York Yankees and Cam Schlittler, who's limited this team to a .252 xBA across 104 plate appearances.
Offense has come from the entire lineup over the last month and change, but nobody has been hotter than Alejandro Kirk, who has 15 hits, three homers, and nine RBI across his nine-game hit streak.
Look for this team to scrape and claw to get three or more runs on the board, especially at one of the most hitter-friendly ballparks in the big leagues.

Blue Jays vs Yankees same-game parlay (SGP)
Yes, the Blue Jays will be going with a bullpen day, but it's a 'pen that's ranked the seventh-best in baseball (3.74 ERA), and one that's rested thanks to Shane Bieber going seven innings yesterday. That should be enough for Toronto to keep things close in a likely low-scoring affair.
Elsewhere, Clement has a variety of ways to cash this bet, and it helps that he feels right at home at Yankee Stadium, owning a .288 average with 17 hits, 12 RBI, and two homers.
Blue Jays vs Yankees SGP
- Blue Jays +1.5
- Blue Jays team total Over 2.5
- Ernie Clement 2+ H/R/RBI
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Blue Jays vs Yankees home run pick: Kazuma Okamoto (+550)
Kazuma Okamoto has hit two homers in his last three games, and has one against Schlittler in his rookie season, too. Okamoto's in the 83rd percentile for barrel percentage (12.5%) and is in a good spot to go yard at Yankee Stadium... again.
- Best bets: 5-5, +3.36 units
- SGPs: 2-7, -0.5 units
- HR picks: 0-9, -2.1 units
Blue Jays vs Yankees odds
- Moneyline: Toronto (+170) | New York (-210)
- Run line: Toronto +1.5 (-125) | New York -1.5 (+105)
- Over/Under: Over 7 (-115) | Under 7 (-105)
Blue Jays vs Yankees trend
The Blue Jays are 4-0 in their last four series openers. Find more MLB betting trends for Blue Jays vs. Yankees.
How to watch Blue Jays vs Yankees and game info
| Location | Yankee Stadium, Bronx, NY |
| Date | Friday, Aug. 21, 2026 |
| First pitch | 7:05 p.m. ET |
| TV | YES, Sportsnet |
| Blue Jays starting pitcher | Mason Fluharty (5-1, 3.71 ERA) |
| Yankees starting pitcher | Cam Schlittler (10-6, 2.19 ERA) |
Blue Jays vs Yankees latest injuries
Blue Jays vs Yankees weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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