Astros vs Red Sox Prediction, Picks & Odds for Today's MLB Game

Shawn Krest - Betting Analyst at Covers.com
Shawn Krest • Betting Analyst 20+ years betting experience
Updated: May 2, 2026 , 01:56 PM ET • 4 min read

The Red Sox are beginning to see results from their sudden staff adjustments and will look to keep that working in their favor as they host the Astros.

MLB

May 01 • 7:10 PM ET
HOU
44 %
BOS
56 %
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Connelly Early Boston Red Sox MLB
Photo By - Reuters Connect. Boston Red Sox pitcher Connelly Early (71) delivers a pitch.

Exactly one week after the “Saturday night massacre” that saw Boston fire manager Alex Cora and five coaches, the Red Sox seem to be responding to the sudden change.

The Red Sox have won four of the six games since the decision was made, matching its best six-game mark of the season.  

Saturday is a rematch with the last-place Astros. My Astros at Red Sox predictions and MLB picks call for a Boston victory.

Who will win Astros vs Red Sox today: Red Sox moneyline (-140)

The Boston Red Sox fired all of their hitting coaches, but left the pitching side intact. Both moves have paid off. 

The Sox have a 2.60 ERA and 1.058 WHIP over the last week, (compared to 4.24 and 1.316 for the season). At the plate, Boston lifted its OPS by 100 points, to 11% over league average, compared to 13% under on the season.

The Houston Astros are hitting but haven’t gotten the clutch hit. In Friday’s series opener, the Astros hit .306 but went 0-for-6 with runners in scoring position.

Over the last four games, Houston is hitting .318 but just .256 with RISP.

Covers COVERS INTEL: The Astros have been even less clutch on the road, posting a stronger 126 OPS+ away from home but averaging fewer runs (4.94) than they do at home (5.31).

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Astros vs Red Sox Over/Under pick: Under 9.5 (-138)

They don’t have the name recognition of other pitchers on the respective staffs but Saturday’s starters have been the best Astro and Red Sox pitchers of the season over the first month-plus.

Houston’s Spencer Arrighetti and Boston’s Connelly Early each have the highest WAR on their team’s pitching staffs.

Arrighetti has won all three of his starts and posted a 2.00 ERA and 1.111 WHIP. He’s given up just one home run over 18 innings. Early has a 2.84 ERA and 1.200 WHIP.

He’s won two of his last three starts. Both pitchers will be facing offenses still trying to find their way.

Shawn Krest's 2026 Transparency Record
  • ML/RL bets: 10-10 +0.48 units
  • Over/Under bets: 12-12 -0.55 units

Astros vs Red Sox odds

  • Moneyline: Houston +113 | Boston -117
  • Run line: Houston +1.5 (-170) | Boston -1.5 (+170)
  • Over/Under: Over 9.5 (+122) | Under 9.5 (-127)

Astros vs Red Sox trend

The Houston Astros have only hit the Moneyline in 6 of their last 24 games (-14.70 Units / -50% ROI). Find more MLB betting trends for Astros vs. Red Sox.

How to watch Astros vs Red Sox and game info

Location Fenway Park, Boston, MA
Date Saturday, May 2, 2026
First pitch 4:10 p.m. ET
TV SCHN, NESN
Astros starting pitcher Spencer Arrighetti
(3-0, 2.00 ERA)
Red Sox starting pitcher Connelly Early
(2-1, 2.84 ERA)

Astros vs Red Sox latest injuries

Astros vs Red Sox weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Shawn Krest
Betting Analyst

Since quitting his job as bank assistant vice-president in 2000, Shawn has covered Final Fours, Super Bowls, World Series games and title fights in boxing and UFC. His work has appeared on ESPN, MLB.com, Sports Illustrated and dozens of other outlets. His book, Baseball Meat Market was published in 2018. He lives in North Carolina with his dog Toby, eight turtles, and wife.

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