Astros vs Mariners Picks and Predictions: Bats Cool Down in Series Finale

Houston and Seattle wrap up their three-game set at T-Mobile Park after splitting the first two contests of the series. With Yusei Kikuchi on the mound, find out if we like the M's to cut into Houston's AL West lead in our Astros vs. Mariners picks.

Zachary Cohen
Posted: Jul 28, 2021 8:31 AM ET Updated: Jul 28, 2021 8:31 AM ET Est Time: 5 min
Yusei Kikuchi Seattle Mariners MLB
Photo By - USA TODAY Sports

The Houston Astros and Seattle Mariners wrap up their three-game set at T-Mobile Park on Wednesday after the teams exchanged victories over the first two contests of the series.

After blowing an eight-run lead in the series opener, Houston almost coughed up another large lead Tuesday night but came away with an 8-6 victory. Now the teams have a quick turnaround with a 3:40 p.m. ET start Wednesday for a pitching matchup that features Jake Odorizzi and Yusei Kikuchi.

Find out who we like in our free MLB betting picks and predictions for Astros vs. Mariners on July 28. 

Astros vs Mariners game info

Location: T-Mobile Park, Seattle, WA
Date: Wednesday, July 28, 2021
Time: 3:40 p.m. ET

Astros vs Mariners odds

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Starting pitchers

Jake Odorizzi (3-5, 4.23 ERA): Odorizzi wasn’t completely healthy at the start of the season, and he’s experienced some up-and-down results throughout the year. In his last two trips to the mound, the righty has allowed seven earned runs in eight total innings, and he walked six batters in those games. However, he had allowed just three earned runs in his previous 22.0 innings before that, flashing his pre-injury form.

Yusei Kikuchi (6-5, 3.95 ERA): After two rough seasons to start his MLB career, Kikuchi is starting to show why so many teams were interested in him a few years back. The lefty has been a solid part of a Mariners rotation that has outperformed expectations this season. The 30-year-old also happened to be great the last time he faced the Astros when he pitched seven innings of shutout ball and struck out seven in a 1-0 win on April 29.


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Astros: Alex Bregman 3B (Out), Pedro Baez RP (Out), Josh James RP (Out).
Mariners: Evan White 1B (Out), Kyle Lewis OF (Out).
Find our latest MLB injury reports.

Betting trend to know

The Mariners are 4-1 in the third game of their last five series. Find more MLB betting trends for Astros vs. Mariners.

Moneyline pick

It’s tough to imagine the Mariners going out and putting up a huge number against Odorizzi, who is a really solid pitcher when he’s healthy. However, Seattle does have a few guys that can give him some trouble here. 

Two players to keep an eye on in this game are Mitch Haniger and Jake Bauers. The two of them are a combined 5-for-17 with a double, a triple, two homers, and nine RBIs against Odorizzi in the past, with each of them taking him yard once.

Haniger is a constant in the Mariners lineup, so they’ll be counting on him to come through for them. Bauers isn’t an everyday starter for Seattle and it’ll be interesting to see if he’s out there. His history against Odorizzi means he could be worth a shot. Ty France is another name to watch, as he's hitting .283 with three homers and 24 RBIs against righties this year. He’s also batting .289 with five homers and 26 RBIs at home. 

While the Mariners seem like they should be able to find at least a modicum of success against Odorizzi, the same can’t exactly be said for the Astros and Kikuchi.

The lefty blanked Houston in seven innings back toward the end of April, showing that he completely figured the Astros out after giving up five runs against them on April 16. A two-run outing seems well within the realm of possibility here. 

PREDICTION: Seattle (+104)

Over/Under pick

Odorizzi hasn’t quite looked like his usual self this season, but he has performed a bit better on the road this year. The righty is 0-3 with a 4.73 ERA when pitching at home on the season, but he is 3-2 with a 3.77 ERA away from Minute Maid Park.

Seattle just so happens to be one of the most pitcher-friendly parks in baseball, so look for the righty to help Under bettors in this game.

Kikuchi, meanwhile, dominated this Astros lineup in his last trip out against them. It’s not realistic to expect the exact same production, but he should be able to limit Houston a bit here. 

PREDICTION: Under 8.5 (-120)

Astros vs Mariners betting card

  • Seattle (+104)
  • Under 8.5 (-120)

Picks made on 7/28/2021 at 12:05 a.m. ET

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