UFC 320 Predictions, Picks & Best Bets for Tonight's Main Card

Get UFC 320 best bets and expert predictions for every main card fight. Break down each matchup with sharp insights from Covers' top analysts.

Chris Vasile - Betting Analyst at Covers.com
Chris Vasile • Betting Analyst
Oct 4, 2025 • 18:00 ET • 4 min read
Magomed Ankalaev (blue gloves) prepares to fight.
Photo By - Imagn Images. Magomed Ankalaev (blue gloves) prepares to fight.

The Octagon lands at T-Mobile Arena in Las Vegas for a Saturday night stacked with bad blood, big swings, and bigger stakes.

Our UFC betting crew — led by Rohit Ponnaiya — has every main-card fight handicapped with expert UFC 320 predictions, picks, and best bets.

UFC 320 best bets

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Ankalaev vs Pereira

Rohit Ponnaiya

Best bet: Ankalaev by KO/TKO or Decision 
-190 at BET99

Six of Ankalaev's previous eight wins have come by decision, but he has power and wobbled Pereira in the second round in the previous fight. The Brazilian has gotten hurt in fights before and has been saved by the bell.  

Read Rohit's full Ankalaev vs. Pereira predictions.


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Dvalishvili vs Sandhagen

Rohit Ponnaiya

Best bet: Dvalishvili by decision 
-170 at BET99

Merab is an elite wrestler who spams takedowns and has excellent control, but he isn't typically a submission threat. Merab is coming off the first sub of his UFC career, and 11 of his last 13 wins have come by decision.

Read Rohit's full Dvalishvili vs Sandhagen predictions.


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Prochazka vs Rountree Jr.

Danny Howard

Best bet: Will the fight go the distance — No
-275 at BET99

This fight will end violently, one way or another. Prochazka’s speed and precision could overwhelm Rountree, or Rountree’s power could fold him with a single shot.

Read Danny's full Prochazka vs Rountree Jr. predictions.


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Emmett vs Zalal

Danny Howard

Best bet: Over 2.5 rounds
-270 at BET99

Whether it’s Zalal grounding things out or Emmett stalking on the feet, there’s going to be a lot of posturing, clinching, and defensive awareness going on that ensures nothing dramatic will happen until later in the fight.

Read Danny's full Emmett vs Zalal predictions.


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Magomedov vs Pyfer

Chris Faria

Best bet: Pyfer by KO or decision
-155 at BET99

Pyfer’s most likely path to victory will be another knockout, but I wouldn’t rule out this one going to a decision. He nearly finished Gastelum early on in his last bout with two knockdowns in the first round, but his output waned as the fight went on.

Read Danny's full Magomedov vs Pyfer predictions.


Our best UFC 320 parlay


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+554 parlay

Tony Sartori

Joe Pyfer by KO/TKO or DQ

Khalil Rountree moneyline

Merab Dvalishvili moneyline

+554 at BET99

Kicking off the main card is a middleweight bout between No. 14-ranked Abus Magomedov and the unranked Joe Pyfer. Despite the ranking difference, Pyfer enters as a -250 favorite.

That line reflects his punching power as he hits harder than almost anyone pound-for-pound, and his clearest path to victory is by KO/TKO. Eight of Pyfer’s last 10 wins have come via knockout. 

Pereira, who headlines Saturday’s main event, has finished Prochazka twice in the second round.  Meanwhile, Rountree was ahead 2-1 on all three scorecards before getting stopped in Round 4 against “Poatan,” showing a better performance against him than Prochazka did.

If Nurmagomedov beat Sandhagen easily and Dvalishvili beat Nurmagomedov, then Dvalishvili should have little trouble with Sandhagen.

At this pace, Dvalishvili is on track to become one of the greatest bantamweights of all time, and Saturday should be another step on that journey.

Read a full analysis of Tony's UFC 320 parlay picks.


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Chris Vasile Covers.com
Betting Analyst

Chris Vasile has been in the betting industry for well over a decade, honing his craft as a writer, editor, and handicapper. Chris has contributed betting and non-betting content for online publications such as ProSportsDaily and The Hockey Writers, in addition to Covers. With a keen interest in soccer, Chris has been featured on Covers' 'Before You Bet', BetMGM Network, and SportsGrid. He also runs his own YouTube channel — Game Day Wagers.

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