| Player | POS | Status | |
|---|---|---|---|
| K. Ort | RP | Sixty Day IL - Elbow ( Thu, Sep 18) | |
| 
                                        The Houston Astros placed RHP Kaleb Ort on the 60-day injured list due to right elbow inflammation.
                                     | |||
| L. Garcia | SP | Sixty Day IL - Elbow ( Thu, Sep 11) | |
| 
                                        The Houston Astros transferred RHP Luis Garcia to the 60-day injured list.
                                     | |||
| J. Rooney | SP | Sixty Day IL - Concussion / Nasal ( Tue, Sep 2) | |
| 
                                        The Houston Astros transferred LHP John Rooney to the 60-day injured list with a left elbow inflammation.
                                     | |||
| B. Walter | RP | Sixty Day IL - Elbow ( Thu, Aug 21) | |
| 
                                        The Houston Astros transferred LHP Brandon Walter to the 60-day injured list with a left elbow inflammation.
                                     | |||
| B. Rodgers | 2B | Sixty Day IL - Oblique ( Sat, Jul 19) | |
| 
                                        The Houston Astros placed INF Brendan Rodgers on the 60-day injured list with a left oblique strain.
                                     | |||
| Z. Dezenzo | RF | Sixty Day IL - Hand ( Thu, Jul 10) | |
| 
                                        The Houston Astros placed INF Zach Dezenzo on the 60-day injured list with a left hand inflammation.
                                     | |||
| P. Leon | RF | Sixty Day IL - Knee ( Mon, Jun 23) | |
| 
                                        The Houston Astros transferred OF Pedro León to the 60-day injured list due to a Grade 1 MCL strain.
                                     | |||
| R. Blanco | SP | Sixty Day IL - Elbow ( Sat, May 31) | |
| 
                                        The Houston Astros transferred RHP Ronel Blanco to the 60-day injured list with a right elbow inflammation.
                                     | |||
| H. Wesneski | RP | Sixty Day IL - Elbow ( Mon, May 19) | |
| 
                                        The Houston Astros transferred RHP Hayden Wesneski to the 60-day injured list from the 15-day injured list with right elbow inflammation.
                                     | |||
| Pitchers | |||
|---|---|---|---|
| POS | # | Player | |
| SP | 43 | Lance McCullers Jr. | |
| SP | 61 | Colton Gordon | |
| SP | 70 | Jayden Murray | |
| Hitters | |||
|---|---|---|---|
| POS | # | Player | |
| LF | 16 | Zach Cole | |
| SS | 14 | Mauricio Dubon | |
| 1B | 17 | Victor Caratini | |
| C | 21 | Yainer Diaz | |
| DH | 4 | Jesus Sanchez | |
| RF | 11 | Cam Smith | |
| 3B | 29 | Ramon Urias | |
| 2B | 28 | Brice Matthews | |
| CF | 31 | Jacob Melton | |