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Get free expert and computer MLB picks for every game on April 22, 2026. With over 25 years of betting experience, our analysts and predictive models help you find the best value.

Los Angeles Dodgers logo LAD @ San Francisco Giants logo SF Tue, Apr 21 • 9:45 PM ET
4 Expert Picks 10 Computer Picks
FirstFiveInnings Run Line
Los Angeles Dodgers logo LAD FirstFiveInnings -0.5 (-115)
Best Odds
Pick made: 6 hours ago
Joe Osborne image
Joe Osborne
Senior Betting Analyst

The Dodgers have a clear early edge, leading MLB in runs scored in innings 1–5 on the road, while the Giants rank dead last at home. Los Angeles is also in better form, leading the league in OPS over the past week compared to San Francisco at 18th. Yoshinobu Yamamoto has been dominant, allowing just two earned runs in his last two starts and has owned Giants hitters, holding them to a combined .485 OPS in 79 at-bats, while Landen Roupp posted a 8.22 ERA in two appearances vs LA last season.

Total
Los Angeles Dodgers logo San Francisco Giants logo u7.5 (-125)
Best Odds
Pick made: 12 hours ago
JD Yonke image
JD Yonke
Betting Analyst

With temperatures in the mid-50s, it should be a pitcher-friendly environment. Yamamoto and Roupp have been two of the better starting pitchers in the league and should thrive. 

There are two quality bullpens behind them as well — L.A. ranks seventh in SIERA in relief (3.45) while San Francisco (3.55) isn’t far behind at ninth and has all of its top options well-rested and at the ready.

View 14 Picks
Los Angeles Dodgers logo LAD @ San Francisco Giants logo SF Wed, Apr 22 • 9:45 PM ET
1 Computer Pick
Strikeouts Thrown
Shohei Ohtani logo
Shohei Ohtani u7.5 Strikeouts Thrown (-154)
Projection 6.07
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 4 out of 5
View Pick

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