There's already plenty of pain around the league as we look at the NFL Week 2 injury updates, including Puka Nacua remaining very uncertain for Monday Night Football.
We're sorting it all out while examining the most significant questions for the prime-time clash to end Week 2, and the potential game-time decisions that will impact your NFL picks.
Latest NFL Week 2 injury updates
Updated at 4:17 p.m. ET on Sunday, Sept. 20.
- Nacua could sit out: Nothing is certain yet, and Puka Nacua benefits from extra time to heal with the Los Angeles Rams playing on Monday Night Football. But the likelihood of him playing seems to be declining due to a groin issue.
- Donald likely back: It's not all bad news for the Rams though, as the triumphant return of Aaron Donald is nearly upon us. Both Donald and head coach Sean McVay expressed optimism earlier this week about the standout pass-rusher making his season debut.
Who will play in NFL Week 2?
Here are the latest updates on the most critical injury situations for Monday Night Football of Week 2.
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NFL Week 2 injury impact
Let's take a deeper dive into a few of the most significant injury situations heading into Week 2 and the potential betting impact.
Ladd McConkey (WR, Chargers)
- Spread: Chargers -6.5 vs. Raiders
- Total: 43.5
- Kickoff: 4:05 p.m. ET
- Location: SoFi Stadium, Inglewood, Calif.
Ladd McConkey's shiftiness and route running make him a target magnet when healthy, as he's logged 100-plus looks in each of his first two NFL seasons. Yes, the Los Angeles Chargers could look more often to deep option Quentin Johnston, but the direct and underrated replacement for McConkey in the slot is Derius Davis.
He's primarily worked on special teams, but Davis ran nine routes from the slot in Week 1. If McConkey is out, he could be a sneaky anytime touchdown long shot ahead of a game against the Las Vegas Raiders, in which Los Angeles is the -6.5 favorite in the NFL Week 2 odds and lines.
Kyler Murray (QB, Vikings)
- Spread: Bears -4.5 vs. Vikings
- Total: 48.5
- Kickoff: 1 p.m. ET
- Location: Soldier Field, Chicago, IL.
It'll be Carson Wentz under center again, and that would be concerning beyond this week for the Minnesota Vikings.
But short-term, a backup who just threw three touchdown passes after Murray departed can be serviceable enough against a leaky Chicago Bears defense. That unit just gave up 37 points against the Carolina Panthers, a game that featured 361 passing yards and three touchdowns from Bryce Young.
If anything, it'll be a chance to capitalize on receiving prop totals for the likes of Justin Jefferson and T.J. Hockenson that might be slightly lower than usual.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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