NFL Week 17 AI Picks: Spread, Moneyline & Total Predictions

Week 17 has arrived right in the heart of Christmas week, and the NFL chaos is coming wrapped with a bow. To make your life easier, we’ve rounded up every spread, moneyline, and total from our AI-powered Covers Predictions in one tidy spot. No tab-hopping, no number hunting, no “wait, what was the line?” moments, just clean, data-driven NFL picks for every game on the slate.

So finish the leftovers, slide back onto the couch, crack something cold, and enjoy the ride from the opening kickoff to the final whistle.

Week 17 NFL picks

Matchup	Spread	ML	Total
@	+7		u51
@	-6.0		o44.5
@	+13.5		o36.5
@	+2.5		o39.5
@	-2.5		o40.5
@	+6.5		u48
@	+5.5		u46.5
@	+4.0		u34.5
@	+13.5		u43.5
@	+3.0		u39.5
@	+7.5		o42.5
@	+7.5		u53.5
@	-1.5		o41.5
@	-1.5		o43.5
@	-2.5		u52.5
@	+8.5		o49.5

Lines courtesy of FanDuel.

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Cowboys vs Commanders

Taking Washington +7 pairs well with a Cowboys moneyline lean: it’s a classic “win but don’t cover” script in a divisional matchup where familiarity compresses variance. The Under is also consistent with a game that can tighten late (more punts/field goals, fewer explosive surprises) if either team plays conservatively with postseason stakes in mind. If this turns into a one-score fourth quarter, the points with the home dog are valuable.

View our matchup Cowboys vs Commanders matchup hub for more stats and analysis prior to kickoff.

Lions vs Vikings

Detroit laying -6 signals a sizable gap, and the Lions ML aligns with that confidence. Over 44.5 suggests the market expects sustained scoring rather than a grind, often a sign both offenses can generate drives and/or the defenses are more bend-than-break. The main risk to a favorite-and-Over combo is red-zone stalls; if Detroit finishes drives with touchdowns, the spread and total can both cash comfortably.

Check out our Lions vs. Vikings matchup hub before game time.

Broncos vs Chiefs

This is a big number, so Chiefs +13.5 is essentially betting on competitiveness: home team, divisional game, and backdoor potential. Broncos ML is a separate stance: Denver can still be the more stable side to win outright even if Kansas City hangs around. Over 36.5 is modest for today’s NFL - it doesn’t take a shootout, just a couple of sustained scoring stretches, to get there.

Looking for more analysis? Check out our Broncos vs. Chiefs matchup hub.

Texans vs Chargers

The split between Texans +2.5 and Chargers ML points to a narrow Chargers win: Los Angeles escapes, Houston keeps it within a field goal. Over 39.5 is a relatively low bar, implying you’re expecting both teams to manufacture points even if the margin stays tight. This angle works best if Houston can keep pace with efficiency and avoid empty red-zone trips, while the Chargers capitalize on a few extra possessions.

View our Texans vs. Chargers matchup hub for more stats and analysis.

Ravens vs Packers

Backing Green Bay -2.5 and ML is a firm home-favorite stance in what profiles as a matchup where execution matters. Over 40.5 suggests scoring opportunities on both sides - think longer drives, play-action shots, and enough explosive plays to offset inevitable stalled possessions. The key for this combo is Green Bay controlling game script: if they play from ahead, the Ravens are forced into more aggressive play-calling, which can lift the total.

Find more stats, results, and trends on our Ravens vs. Packers matchup hub.

Jaguars vs Colts

Colts +6.5 with Jaguars ML is another “win close” setup: Jacksonville edges it, Indianapolis stays live all game. Under 48 complements that; if this is a tighter, more methodical contest, the margin likely remains within one score. This bet shape typically benefits from clock-consuming drives, a few field goals, and limited short fields. If turnovers create sudden points, the Under becomes the vulnerable leg.

View our Jaguars vs. Colts matchup hub for more stats and analysis prior to kickoff.

Buccaneers vs Dolphins

This is a hedged profile: Tampa to win, Miami to cover. That implies a tight game where the Bucs are trusted slightly more in late-game execution, while the Dolphins keep it within one possession. Under 46.5 reinforces a more controlled pace (or tougher red-zone outcomes) than the total suggests on paper for these teams. If either side hits multiple explosive plays early, you’ll want Tampa’s ML to do the heavy lifting.

Looking for more info? We have you covered on our Buccaneers vs. Dolphins matchup hub.

Steelers vs Browns

Under 34.5 is the headline, and this projects as a defensive, field-position game where every possession matters. Steelers ML with Browns +4 again points to a very narrow Pittsburgh win. In ultra-low totals, points become even more valuable, so taking +4 is logical. This setup cashes best if both teams are forced to string together long drives rather than scoring quickly. One defensive touchdown can swing everything, especially against such a low number.

Visit our Steelers vs. Browns matchup hub ahead of kickoff.

Patriots vs Jets

Jets +13.5 is a “keep it respectable” play with a Patriots ML lean: New England can be the steadier side while the large spread accounts for volatility and late backdoor scoring. Under 43.5 suggests you’re not expecting sustained offensive efficiency with more missed opportunities than fireworks. The combination makes sense if the Jets’ defense keeps them attached and the game pace stays moderate. If turnovers pile up, the spread can still cash while the Under sweats.

Dive into our Patriots vs. Jets matchup hub for more key stats and trends ahead of the game.

Saints vs Titans

Saints ML with Titans +3 implies a coin-flip game where New Orleans is favored slightly to finish, but Tennessee’s home-field and style keep it within a field goal. Under 39.5 fits a lower-tempo contest with fewer total possessions, more punting and field-goal attempts. This bet construction is essentially “Saints win a grinder.” If either team jumps out early, it can force the other into higher-variance aggression and threaten the Under.

Check out our Saints vs. Titans matchup hub for a bonus score prediction.

Seahawks vs Panthers

Seahawks ML is the straightforward side, but Panthers +7.5 expects Carolina to stay competitive enough to avoid a blowout. Over 42.5 signals a game with more scoring than the underdog narrative might suggest, often driven by defensive lapses, short fields, or a pace increase from negative game scripts. If Seattle leads for long stretches, Carolina’s need to push the ball can create both points and volatility, helping the Over and the big dog cover.

Bolster your handicap by visiting our Seahawks vs. Panthers matchup hub.

Cardinals vs Bengals

With a huge total, Under 53.5 is essentially betting against a track meet. Bengals ML suggests Cincinnati is the more trustworthy winner, while Cardinals +7.5 respects Arizona’s ability to hang around even if they don’t finish. The angle here is “competitive but not wild” with enough scoring to keep it interesting, but not the full-blown shootout implied by a mid-50s number. If either defense forces a couple long, clock-draining drives, the Under gains leverage.

Browse our matchup Cardinals vs. Bengals hub to see more stats, picks, and up-to-the-minute odds.

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Giants vs Raiders

Raiders -1.5 and ML is a clean home lean in a near pick’em. Over 41.5 expects this game to clear a modest scoring bar, often helped by fourth-quarter urgency if it stays tight. The risk with small spreads is that one or two high-leverage plays decide the outcome; the over can still land even if the side flips. If you like Las Vegas here, you’re effectively betting they create the higher-quality chances and convert enough of them.

See our Giants vs. Raiders matchup hub for more news you can use.

Eagles vs Bills

This is a “Bills in a close, high-quality game” position. Laying only -1.5 means you’re mostly just asking Buffalo to win at home. Over 43.5 suggests both teams can generate scoring drives and that neither defense is expected to fully dictate terms for four quarters. This combo performs best when Buffalo’s offense maintains rhythm and Philadelphia matches enough to keep aggression high into the second half with fewer punts and more fourth-down tries.

Find the latest odds and stats on our Eagles vs. Bills matchup hub.

Bears vs 49ers

San Francisco -2.5 and ML is a confident lean in a relatively short line. Under 52.5 suggests you’re fading a full shootout and expecting at least one side to control tempo or force red-zone compromises. This pairing fits a script where the 49ers dictate pace, sustain drives, and keep Chicago from turning it into a track meet. If the Bears hit multiple explosives, the Under becomes the sweat despite the Niners side landing.

Explore our Bears vs. 49ers matchup hub for advanced stats and betting angles ahead of kickoff.

Rams vs Falcons

Rams ML with Falcons +8.5 is the classic “favorite wins, dog covers” structure, and over 49.5 suggests the path is scoring, not a slow squeeze. If Los Angeles wins while Atlanta trades enough punches to stay within one score, both bets align. In high totals, +8.5 is meaningful because a late touchdown can swing the cover even in a comfortable loss. The biggest threat is a Rams defensive takeover that suppresses Atlanta’s scoring and drags the total down.

Get the latest news and injury updates from our Rams vs. Falcons matchup hub now.

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