NFL Week 16 AI Picks: Spread, Moneyline & Total Predictions

Week 16 has arrived, and the NFL chaos is officially dialed up. To make your life easier, we’ve rounded up every spread, moneyline, and total from our AI-powered Covers Predictions in one tidy spot. No tab-hopping, no number hunting, no “wait, what was the line?” moments, just clean, data-driven picks for every game on the slate.

Lock in your NFL picks, settle in, crack something cold, and enjoy the ride from the opening kickoff to the final whistle.

Week 16 NFL picks

Matchup	Spread	ML	Total
@	+2		o42
@	+6.5		u44.5
@	+1.5		u47
@	+10.5		u42.5
@	+3.0		o46
@	+3.0		o44
@	-2.0		u50
@	+4.5		o40
@	-3.0		u37.5
@	+4.5		u48
@	+3.0		o48
@	-2.5		u47
@	-6.5		u52.5
@	+14.5		o37.5
@	+3.0		u48.5
@	+6.5		o46.5

Lines courtesy of FanDuel.

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Rams vs Seahawks

Backing the Rams both +2 and on the moneyline signals a belief they can win outright despite being a small road underdog. Pairing that with Over 42 implies you’re expecting enough offensive efficiency (or short fields) to clear a modest total, rather than a grind. This combo generally fits a game script with sustained drives and a couple explosive plays, where a late possession decides it.

View our matchup Rams vs. Seahawks matchup hub for more stats and analysis prior to kickoff.

Eagles vs Commanders

This is a classic “win but don’t cover” profile: Eagles to win, but Washington to stay within a touchdown. Under 44.5 supports that logic as fewer total points makes +6.5 more valuable, and close, lower-scoring games land inside that number more often. You’re effectively betting the Eagles’ edge shows up over four quarters, but without enough scoring separation to create a comfortable margin.

Check out our Eagles vs. Commanders matchup hub before game time.

Packers vs Bears

Taking the Packers +1.5 and ML means you’re calling for a narrow Green Bay win in a near pick’em. Under 47 aligns with that: lower totals typically compress margins and keep one-score outcomes in play. The handicap is basically “Packers do slightly more right” in a divisional-style matchup where mistakes, field position, and finishing drives matter more than pure volume scoring.

Looking for more analysis? Check out our Packers vs. Bears matchup hub.

Bills vs Browns

Another split: Bills to win, Browns to hang around. +10.5 is a big cushion in a game lined to be relatively low scoring at 42.5, where double-digit spreads are harder to justify without multiple-score separation. This card fits a controlled Bills win (steady advantage, but not a runaway) while the Under leans toward fewer possessions and fewer “quick strike” points.

View our Bills vs. Browns matchup hub for more stats and analysis.

Buccaneers vs Panthers

Buccaneers ML with Panthers +3 implies a close Tampa win: enough to survive, not necessarily enough to clear the number. Over 46 is the more aggressive piece as you’re asking for both teams to contribute, or for one side to score efficiently with the other adding enough to push it past the total. This works best when the game stays live deep into the fourth quarter.

Find more stats, results, and trends on our Buccaneers vs. Panthers matchup hub.

Vikings vs Giants

This set says Vikings win, but the Giants keep it within a field goal at home. Over 44 suggests a more open scoring environment—when points come easier, +3 has extra value because late scores can flip a cover without changing the winner. The story here is a competitive game with enough successful drives to get into the mid-40s, decided by one late stop or kick.

View our Vikings vs. Giants matchup hub for more stats and analysis prior to kickoff.

Chargers vs Cowboys

You’re leaning Dallas to win and cover a small number (-2), essentially treating it as a near coin flip but giving the Cowboys the edge at home. Under 50 says you don’t need a shootout for that to happen; in fact, a steadier, lower-variance game often benefits the side you trust more. This ticket fits Dallas controlling key downs and avoiding the kind of track meet that invites upset variance.

Looking for more info? We have you covered on our Chargers vs. Cowboys matchup hub.

Jets vs Saints

Saints ML with Jets +4.5 again targets a close Saints win. The total is low (40), so going Over doesn’t require fireworks, just a cleaner offensive game than the number implies. In low-total games, +4.5 is meaningful because one-score margins are common; pairing it with the over suggests you still expect enough scoring (or a couple short fields) to get into the low-to-mid 40s.

Visit our Jets vs. Saints matchup hub ahead of kickoff.

Chiefs vs Titans

Chiefs -3 and ML is straightforward: win by more than a field goal. The interesting part is Under 37.5, a very low total that implies limited scoring chances, so you’re betting Kansas City can create enough separation in a game where points are at a premium, even without Patrick Mahomes in the lineup. This fits a script where the Chiefs’ efficiency on key possessions matters more than volume, and where one turnover/short-field TD could decide both spread and total.

Dive into our Chiefs vs. Titans matchup hub for more key stats and trends ahead of the game.

Bengals vs Dolphins

This is another “Bengals win, Dolphins cover” card, with Under 48 reinforcing the idea that the game doesn’t become a full-on scoring race. With an Under, every point of spread value matters more, and +4.5 covers a lot of common end states (field-goal game, late TD making it tight). You’re essentially fading a runaway and backing a competitive four quarters.

Check out our Bengals vs. Dolphins matchup hub for a bonus score prediction.

Falcons vs Cardinals

Falcons ML but Cardinals +3 points to a tight Atlanta win, and Over 48 says you expect enough scoring to keep the door open for a late cover. High totals often correlate with closer finishes because teams trade scores and margins swing quickly. This ticket makes sense if you believe Atlanta has the steadier endgame, while Arizona can match stretches of production, setting up a one-possession result in a higher-scoring context.

Bolster your handicap by visiting our Falcons vs. Cardinals matchup hub.

Jaguars vs Broncos 

Backing Denver -2.5 and ML is a firm stance that the Broncos win at home and clear a small number. Under 47 suggests you’re not counting on an offensive eruption—more like a game where a handful of drives and situational edges decide it. The -2.5 is also notable because it avoids the push risk at -3. This profile fits a 3–7 point type win in a moderate-scoring game.

Browse our matchup Jaguars vs. Broncos hub to see more stats, picks, and up-to-the-minute odds.

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Steelers vs Lions

Lions -6.5 plus ML is a confident favorite position—win by about a touchdown or more. Under 52.5 doesn’t demand a slow game, just not a full track meet; it pairs with the idea of Detroit winning with control rather than trading haymakers. This combination often looks best when the favorite leads for long stretches, forces the opponent into predictable late possessions, and limits cheap points that threaten both cover and Under.

See our Steelers vs. Lions matchup hub for more news you can use.

Raiders vs Texans 

Texans ML with Raiders +14.5 is the “favorite wins, but not a blowout” angle—huge points with the dog. Over 37.5 is relatively low, so the Over can cash even if one team does most of the scoring, or if the underdog contributes late. The key to +14.5 is simply avoiding long empty stretches and catastrophic turnovers; the total says you don’t need much help to get into the 40s.

Find the latest odds and stats on our Raiders vs. Texans matchup hub.

Patriots vs Ravens

Ravens ML with Patriots +3 again targets a close Baltimore win. Under 48.5 supports the spread split: in mid/low-scoring games, +3 is powerful because common outcomes cluster around one-score margins. This card fits a game where Baltimore has the higher win probability, but New England can keep the scoreline tight through pacing, field position, and forcing a few empty drives, landing on a 3-point type finish.

Explore our Patriots vs. Ravens matchup hub for advanced stats and betting angles ahead of kickoff.

49ers vs Colts

This one says San Francisco wins, but Indianapolis stays within a touchdown at home. Over 46.5 adds a “points are there” expectation: when totals climb, underdogs often benefit from backdoor opportunities and trading scores. So the story is 49ers are the better side to win outright, but the Colts can keep scoring pressure on them enough that the margin doesn’t balloon beyond one possession.

View our 49ers vs. Colts matchup hub ahead of kickoff.

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