It’s been a nightmare first month for the Baltimore Ravens, and now Lamar Jackson’s hamstring injury hangs over their Week 6 clash with the Los Angeles Rams.
Both teams are coming off a loss, but Baltimore’s embarrassing 44-10 collapse on Sunday was on another level, and my Rams vs Ravens predictions expect Matthew Stafford to have a field day at M&T Bank Stadium.
Get the lowdown on this October 12 matchup with my NFL picks and betting angles.
Rams vs Ravens predictions
Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.
Early Rams vs Ravens spread pick: -7.5
There’s no getting around the drop-off from Lamar Jackson to Cooper Rush under center for the Baltimore Ravens, but that’s not even the biggest issue for the hosts to address heading into Week 6.
While Rush ended up tossing three interceptions over the weekend, Baltimore was already playing catch-up by that point after its defense was shredded by C.J. Stroud — who completed 23 of his 27 passes on the way to four TDs.
The Houston Texans have sputtered offensively for most of the season, but the Ravens made them look like world-beaters.
So, though this is a big line for the Los Angeles Rams on the road, I prefer to lay the points with an L.A. offense headlined by Puka Nacua, who leads the NFL in receiving yards.
The visitors are 3-0 this year against the AFC and 7-3 ATS in their last 10 games overall. They also have the rest advantage in their favor.
Meanwhile, the Ravens are 1-4 ATS this season, and this line clearly points to Jackson missing at least another week. Without him, the scoreline could get out of hand in a hurry, especially as Baltimore has allowed 37+ points in four of its five outings this year.
John Harbaugh is standing by his defensive staff for now, but the situation isn’t likely to get better with Matthew Stafford and Sean McVay coming to town.
Early Rams vs Ravens total pick: Over 45.5
There are some shaky defenses across the league, but the Ravens are rock bottom through the first five weeks, allowing 35.4 PPG. With injuries mounting, Baltimore is allowing 408.8 yards per contest.
The Over has been a winning ticket in all of the Ravens’ outings this season, while the Rams have scored 26+ points in four of their past five games and boast one of the NFL’s most balanced offenses. The Over is also 5-3 in the visitors’ last eight matchups.
Costly fumbles and penalties derailed L.A. last Thursday in a gut-wrenching 26-23 OT loss to the San Francisco 49ers, but Stafford still finished with 389 passing yards, three TDs, and no picks.
With Nacua, Davante Adams, and Tutu Atwell to stretch a banged-up Baltimore secondary to breaking point, I see the visitors putting on a clinic on the road here.
The biggest concern for the Over is the potential for Derrick Henry to be bottled up by a talented Rams front seven, leaving the offense squarely in Rush’s hands.
Still, the Ravens have some big-play threats, and I’m wagering another week of prep for their stand-in QB will drive slight improvements from the hosts.
Rams vs Ravens odds
- Rams vs. Ravens spread: Ravens +7.5
- Rams vs. Ravens moneyline: Rams -420, Ravens +330
- Rams vs. Ravens Over/Under: 45.5
How to watch Rams vs Ravens
- Rams vs. Ravens matchup
- Date: Sunday, October 12, 2025, 1:00 p.m. ET
- City: Baltimore, MD
- Venue: M&T Bank Stadium
- TV: FOX
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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