Christian McCaffrey Odds, Picks & Predictions for Divisional Round

Although Christian McCaffrey was a non-factor in San Francisco’s regular-season finale against Seattle, we expect the 49ers running back to shine in tonight's rematch.

Trevor Knapp - Betting Analyst at Covers.com
Trevor Knapp • Betting Analyst
Jan 17, 2026 • 07:00 ET • 4 min read
Christian McCaffrey San Francisco 49ers NFL
Photo By - Reuters Connect. San Francisco 49ers running back Christian McCaffrey (23).

The San Francisco 49ers will look to flip the tables on the NFL odds for a second straight week when they head to the Emerald City to face the Seattle Seahawks in the Divisional Round.

San Francisco’s offense was held in check by Seattle back in Week 18, but the Christian McCaffrey odds expect a bounce back from the 49ers' superstar running back.

Find out more in our NFL player prop projections for Saturday, January 17.

Christian McCaffrey predictions for the Divisional Round

Market Proj. Odds Value
Rushing yards
(54.5)
70.4 Over 54.5
-114
A+
Anytime touchdown
(0.5)
0.82 Over 0.5
-130
A+
Receiving yards
(51.5)
56.8 Over 51.5
-114
A
Receptions
(6.5)
5.9 Under 6.5
-148
B+

Christian McCaffrey averaged 70.7 rushing yards per game during the regular season, and our projections suggest a similar output tonight at Lumen Field.

The Niners' swiss-army knife is also expected to top his receiving total, and he's fresh off 66 receiving yards in last weekend's Wild Card win over the Eagles. McCaffrey even found the end zone twice in that outing, and our computer is listing an A+ play for him to find paydirt against the Seahawks. 

FanDuel is also offering a 30% profit boost token for anytime TD wagers, which would boost McCaffrey’s anytime TD odds from -140 to +123 if applied.

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Christian McCaffrey same-game parlay for the Divisional Round

Over 54.5 rushing yards

Anytime touchdown

Over 51.5 receiving yards

CMC is bound for a big night both on the ground and through the air, and with George Kittle out, an anytime touchdown makes for a strong SGP at better than 3/1 odds.


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Trevor Knapp - Covers
Betting Analyst

Trevor joined the Covers content team as a publishing editor in early 2022. Growing up in Vancouver, he studied Broadcast and Online Journalism at the British Columbia Institute of Technology (BCIT), and interned with TSN and Sportsnet Radio while also writing for the Daily Hive.

An avid bettor of the MLB, NFL, and CFL, Trevor advises his fellow sports bettors to leave their hearts at the door and not hesitate to fade their favorite team. It's a strategy he follows regularly as an apathetic Indianapolis Colts and Toronto Blue Jays fan.

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