Anytime Touchdown Scorer 49ers vs Rams Prediction: TD Picks for Thursday Night Football Week 5

While the Niners' offense isn't nearly as good this year, they need to get the ball in the hands of their best playmaker when it counts.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
Oct 1, 2025 • 12:28 ET • 4 min read
Christian McCaffrey San Francisco 49ers NFL
Photo By - Imagn Images. San Francisco 49ers running back Christian McCaffrey (23).

The San Francisco 49ers and Los Angeles Rams lock horns in a clash of NFC West rivals on Thursday Night Football. 

49ers running back Christian McCaffrey led the NFL with 21 touchdowns two years ago, while Rams wideout Davonte Adams boasted a league-high 18 receiving TDs in 2020.

Although the Niners' offense has taken a step back and Adams is on the back end of his career, my NFL picks are backing both players to find paydirt on Thursday.

Here are my best free 49ers vs Rams anytime touchdown picks for October 2. 

49ers anytime touchdown pick

Christian McCaffrey (-135 at bet365)

Christian McCaffrey is 29 years old, but he's being fed the ball more than at any time in his career.

With the San Francisco 49ers decimated by injuries at receiver, they're using the superstar running back in the passing game even more than usual. Through four games, McCaffrey has 69 rush attempts for 225 yards while racking up 31 catches for another 305 yards through he air.

McCaffrey has struggled to run the ball in the red zone this year, rushing 16 times for just 10 yards. That said, he's collected five catches in the red zone for a pair of touchdowns. The fact that he's getting such a high usage rate inside the 20-yard line bodes well for his long-term ability to find paydirt. 

Don't forget that just two years ago, McCaffrey led the league with 21 touchdowns, en route to winning the NFL Offensive Player of the Year Award. Expect CMC to find paydirt at SoFi. 

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Rams anytime touchdown pick

Davante Adams (+110 at bet365)

Los Angeles Rams wideout Puka Nacua has been the most productive receiver in the league, but teammate Davante Adams has been getting more looks in the red zone. 

Nacua leads the NFL with 50 targets this year, but only three of those have come inside the RZ. Meanwhile, Adams has been targeted 10 times inside the 20s, converting those throws into a pair of touchdowns. 

Adams isn't the elite player he was in his prime, but he's still a dangerous weapon who has settled into the No. 2 WR role in L.A. With defenses focused on stopping Nacua, Adams can take advantage of matchups against weaker defensive backs. 

Odds are correct at the time of publishing and are subject to change.
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Rohit Ponnaiya
Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

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