Best 49ers vs Rams Same Game Parlay for Thursday Night Football Week 5

Check out our +910 SGP for TNF, which keys on Davante Adams leading the way on offense for the Rams vs. the 49ers.

Robert Criscola - Betting Analyst at Covers.com
Robert Criscola • Betting Analyst
Oct 2, 2025 • 10:00 ET • 4 min read
Los Angeles Rams Davante Adams NFL
Photo By - Imagn Images. Los Angeles Rams wide receiver Davante Adams (17) celebrates after a touchdown.

First place in the NFC West is on the line on Thursday Night Football when the San Francisco 49ers take on the Los Angeles Rams to kickstart Week 5 of the NFL season.

We taken our best 49ers vs. Rams predictions and made a same-game parlay that offers over +900 odds! Read on for our free NFL picks and 49ers vs. Rams SGP predictions for October 2.

Our best 49ers vs Rams SGP for Week 5

The San Francisco 49ers snuck by the Seahawks, Saints, and Cardinals in their first three games before losing as a home favorite against the Jaguars last week.

The level of competition rises significantly on Thursday Night Football against the Los Angeles Rams, a team that typically typically takes care of business for chalk-players. Los Angeles is 11-4 ATS in its last 15 games as a favorite, with just one outright loss in this span.

This game sets up quite nicely for Matthew Stafford and the Rams pass attack.

Stafford should have plenty of time to work in the pocket, as the 49ers have struggled to disrupt opposing QBs so far this season. They enter this matchup ranked 29th in pressure rate and have just five total sacks.

San Francisco also ranks 25th in opponent completion percentage, and they’ve yet to face a passing game as dangerous as that of the Rams (fifth in yards per pass attempt).

Davante Adams, who's had 50+ yards in every game this season, stands to benefit from this matchup. His presence should be most keenly felt in the red zone, as he's tied for league lead in targets inside the 20-yard line.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Robert Criscola - Covers.com
Betting Analyst

Robert M. Criscola’s road to becoming a Covers publishing editor began with an internship at Metro New York, which eventually turned into a freelance job at MetroBet covering many sports from a wagering angle, including horse racing. He continued to focus on “The Sport of Kings” by writing for shapperdacapper.com, danonymousracing.com, and informer.fanxt.com before joining the team at the TwinSpires Edge in 2019 as a regular contributor and weekend editor. “Crisco” began writing game previews for Covers in 2022 and joined the editing team in 2023.

His best advice for sports bettors? Bet with your head, not over it.

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