Christian McCaffrey and the San Francisco 49ers upset the Eagles last week, but now they head to Lumen Field on Saturday to face the No. 1-seed Seattle Seahawks.
While I expect C-Mac to add to his touchdown tally, Cooper Kupp also presents strong upside for a Seattle team that should have no trouble finding the end zone.
Here are my best free 49ers vs. Seahawks anytime touchdown picks for the NFC Divisional Round on January 17.
For more NFL picks, make sure to check out our full 49ers vs. Seahawks predictions!
49ers anytime touchdown pick
Christian McCaffrey (-130 at FanDuel)
I don’t expect the San Francisco 49ers to generate much offense in this game, so it makes sense to go chalky with my anytime touchdown prop. If the Niners are going to score, there’s a strong chance it will come via Christian McCaffrey.
The Pro Bowl running back is a dual threat, capable of scoring on the ground and through the air. He’s recorded an incredible 98 red-zone touches this season (74 carries and 20 receptions), resulting in 17 total touchdowns.
C-Mac punched the ball into the end zone twice against Philadelphia last week and has scored in seven of his last eight games.

Seahawks anytime touchdown pick
Cooper Kupp (+310 at FanDuel)
Meanwhile, I could see the Seattle Seahawks putting up plenty of points against a San Francisco defense that ranks 30th in the league in success rate. That opens the door for several Seahawks playmakers to get in on the scoring action.
One of those is wide receiver Cooper Kupp. The veteran wideout was targeted 12 times in the red zone during the regular season, with eight of those coming in the final six weeks after Tory Horton suffered a season-ending injury.
Kupp is a reliable route-runner with sticky hands, and his experience is invaluable on a young team. That could make Sam Darnold look his way, especially with the Niners' defense focused on stopping Jaxon Smith-Njigba.
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