The Iowa Hawkeyes look to finish their Big Ten season in high style when they visit historic Memorial Stadium and the Nebraska Cornhuskers.
With the Hawkeyes built to excel in inclement weather, my Iowa vs. Nebraska predictions expect the visitors to dominate the trenches and win by a comfortable margin.
Read on for my college football picks for Friday, November 28.
Iowa vs Nebraska prediction
Iowa vs Nebraska best bet: Iowa -6.5 (-106)
The Iowa Hawkeyes are built to play in lousy weather, and the expected mix of snow, sleet, and rain is as awful as it gets.
The Hawkeyes thrive in low-scoring, trench-heavy games, and this matchup and the horrible weather set Iowa up perfectly to win this game by a comfortable margin.
Iowa owns clear advantages in run defense, allowing just 101.6 rushing yards per game and 3.21 yards per carry, and its stout rushing offense should find success against a Nebraska front giving up 167.5 rushing yards per game.
With the foul weather limiting Nebraska’s sometimes explosive passing plays, the Cornhuskers’ already-thin receiving corps and backup freshman quarterback TJ Lateef face an uphill battle moving the ball through the air.
Iowa should control the trenches, and its ability to control field position makes the Hawkeyes the more reliable side.
Enjoying Covers content? Add us as a preferred source on your Google account
Iowa vs Nebraska same-game parlay
Nebraska quarterback TJ Lateef has a good arm, but the weather and the Hawkeyes' exceptional passing defense should keep Lateef Under his passing yards total.
With snow and sleet expected and a Nebraska secondary allowing fewer than 10 yards per completion, the conditions point strongly toward Mark Gronowski staying Under his passing yards total.
Iowa vs Nebraska SGP
- Iowa -6.5
- TJ Latleef Under 141.5 passing yards
- Mark Gronowski Under 134.5 passing yards
Our deep-ball SGP: Gron smash
Gronowski has rushed for more than 33 yards twice in his past five games and has scored at least one touchdown in 10 of 11 games this season.
Iowa vs Nebraska SGP
- Iowa -6.5
- TJ Latleef Under 141.5 passing yards
- Mark Gronowski Under 134.5 passing yards
- Mark Gronowski Over 32.5 rushing yards
- Mark Gronowski anytime touchdown
Iowa vs Nebraska odds
- Spread: Iowa -6.5 (-106) | Nebraska +6.5 (-114)
- Moneyline: Iowa -230 | Nebraska +194
- Over/Under: Over 39.5 (-105) | Under 39.5 (-115)
Iowa vs Nebraska trend to know
Iowa has covered the spread in seven of their last 13 games (+2.64 Units / 19% ROI). Find more college football betting trends for Iowa vs Nebraska.
How to watch Iowa vs Nebraska
| Location | Memorial Stadium, Lincoln, NE |
| Date | Friday, November 28, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | CBS |
Iowa vs Nebraska latest injuries
Iowa vs Nebraska weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
