The Michigan Wolverines suffered their first loss of the season last week after Michigan State stunned them with a late rally. That loss hurt Michigan’s chances at a College Football Playoff spot... but the dream isn’t over just yet.
The Wolverines will have to run the table to remain relevant, starting with a home matchup against an underwhelming Indiana Hoosiers team — where college football betting odds have installed Michigan as a nearly three-touchdown favorite.
Here are our best free college football picks and predictions for Indiana vs. Michigan on Saturday, November 6.
Indiana vs Michigan odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
Michigan opened as a 19-point favorite and is currently sitting at -20.5 at the time of writing. However, while Michigan’s spread increased, the total has held at the opening mark of 51. Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.
Indiana vs Michigan picks
Picks made on 11/4/2021 at 5:11 p.m. ET.
Click on each pick to jump to the full analysis.
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Indiana vs Michigan game info
• Location: Michigan Stadium, Ann Arbor, MI
• Date: Saturday, November 6, 2021
• Time: 7:30 p.m. ET
• TV: FOX
Indiana vs Michigan betting preview
Weather
Be sure to monitor the gametime conditions with our NCAA football weather info.
Key injuries
Indiana: Michael Penix Jr. QB (Out), Jack Tuttle QB (Doubtful).
Michigan: Donovan Edwards RB (Questionable).
Find our latest NCAA football injury reports.
Betting trend to know
The Wolverines are 8-2 ATS in their last 10 games as a home favorite. Find more NCAA betting trends for Indiana vs. Michigan.
Indiana vs Michigan predictions
Michigan -20.5 (-110)
The Michigan Wolverines lost a stunner to the Michigan State Spartans last week, blowing a 30-14 third-quarter lead in an eventual 37-33 defeat. All Michigan can do is put the game behind it and move on.
The Wolverines will look to rebound against a struggling Indiana team that is now onto its third quarterback of the season. Backup QB Jack Tuttle, who was elevated following Michael Penix Jr.'s injury five weeks ago, is doubtful, meaning true freshman Donaven McCulley will get his second start of the season.
McCulley went 14 for 25 against Maryland for 242 yards and two touchdowns last week, but it wasn’t enough as Indiana suffered a close 38-35 road loss to the Terrapins. McCulley finished the day with a QBR of just 44.4 — which wasn't good enough against Maryland and certainly won’t fly against Michigan.
The Wolverine's defense is one of the best in the Big Ten: The defensive line does very well at generating pressure on the QB also getting through the offensive line for tackles in the backfield. For Indiana, the rushing defense is its best aspect, as the Hoosiers have allowed 126.1 yards per game on the ground this season. However, the coverage is weak and the pass rush isn’t much better.
With freshman receiver Andrel Anthony starting to come around, Michigan might elect to throw a little more today and see what he is capable of, which could add another element to a Michigan offense that already averages 37.1 points and 456.5 yards per game.
We’ll take Michigan at -20.5 in this game. There’s no way you can back a third-string quarterback against this Michigan defense.
Under 51 (-110)
Indiana is scoring just 22 ppg this year and although McCulley helped Indiana reach 35 points last week, that’s not going to happen this week against Michigan.
Also, the Wolverines are a run-first offense but Indiana has held opponents in check-in the ground game this year. If there’s anything to brag about with this 2-6 Hoosiers team, it’s that Indiana has a solid rushing defense.
A couple stops here and there on the ground will help the clock tick away — and the Under cashes for bettors.
Did you know that if you parlayed our Indiana vs. Michigan picks, you could win $26.45 on a $10 bet?
Use our college football parlay calculator to create your own parlays and see their potential payouts.
