USC vs Arizona State Picks and Predictions: Trojans on the Attack

Both of these sides look pretty fadeable, but something's got to give as the Trojans and Sun Devils face off. Find out who we're siding with for college football betting as we break down our USC vs. Arizona State picks.

Last Updated: Nov 5, 2021 11:02 AM ET Read Time: 5 min
Keaontay Ingram USC Trojans college football
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A matchup between two reeling teams goes down Saturday night in the Pac-12 between the Trojans and the Sun Devils. USC snapped a two-game losing streak by barely hanging on to oust a bad Arizona team, while Arizona State enters off two straight losses and a bye week to stew on them.

Things were looking promising for Arizona State a few weeks ago, but now it has fallen behind in the Pac-12 standings and the fans are chanting to replace coach Herm Edwards. 

Check out our picks and predictions for the USC Trojans vs. the Arizona State Sun Devils on Saturday, November 6.

USC vs Arizona State odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

This lined opened Arizona State -8.5 and currently sits between -8.5 and -9.5 depending on the book.

Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.

USC vs Arizona State picks

Picks made on 11/5/2021 at 10:05 a.m. ET.
Click on each pick to jump to the full analysis.

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USC vs Arizona State game info

Location: Sun Devil Stadium, Tempe, AZ
Date: Saturday, November 6, 2021
Time: 10:30 p.m. ET

USC vs Arizona State betting preview


Be sure to monitor the gametime conditions with our NCAA football weather info.

Key injuries

USC: Drake London WR (Out), Bru McCoy WR (Out), Josh Falo TE (Out), Kenan Christon RB (Out), Michael Trigg TE (Questionable), Nick Figueroa DL (Questionable), Jamar Sekona DL (Questionable), Greg Johnson S (Questionable)
Arizona State: Jermayne Lole DL (Out), Johnny Wilson WR (Questionable), Chase Lucas CB (Questionable), Evan Fields CB (Questionable), Omarr Norman-Lott DL (Questionable), Rachaad White RB (Probable)
Find our latest NCAA football injury reports.

Betting trend to know

The Sun Devils are 2-9 ATS in their last 11 games as a home favorite. Find more NCAA betting trends for USC vs. Arizona State.

USC vs Arizona State predictions

In a matchup between two teams somewhere between “in decline” and “freefall,” we’ll take the underdog catching over a touchdown. This isn’t necessarily a play with the utmost confidence in USC as a team, but rather a play to the number in a game between two volatile teams. We’ll take the best number we can get in this matchup, as the offerings range from +8.5 to +9.5 depending on the book. 

Arizona State has been playing with a dark cloud hanging over its heads all seasons with the news of a recruiting scandal dropping. The team got off to a hot start, winning five of its first six games, but the cracks have started to show in the armor. The Sun Devils have lost two straight and Herm Edwards’s coaching seat is suddenly a few degrees warmer. That’s what back-to-back two-score losses to Utah and Washington State will do.

You can point out that Arizona State is 4-1 at home, but look at the opponents: Southern Utah, UNLV, Colorado, Stanford, and Washington State — they managed to lose one of those by double digits! 

True, USC will be without its best player after Drake London fractured his ankle against Arizona. The offense is ranked 22nd in the country with 457.6 total yards per game and has a reinvigorated running game led by Texas transfer Keaontay Ingram, so it should be able to move the ball regardless. The insertion of freshman Jaxson Dart into the quarterback rotation has given this offense an element of explosiveness, and game planning for two quarterbacks (one of whom has limited game film to study) is never easy for opposing coaches.

Arizona State has done little to inspire confidence lately. It’s been up-and-down, as has USC, but this isn’t a point in the season where laying over a touchdown is advisable. The Sun Devils have also failed to protect their home turf, going just 2-9 ATS in their last 11 games as a home favorite.

You won’t find me playing many Unders with USC this season. The Trojans can move the ball effectively, averaging a robust 6.3 yards per play this season. The running game has taken off under Ingram, who has 51 carries in the last two games and ran for over 200 yards last week against Arizona (it would have been well over 300 yards, but multiple long runs were erased due to penalties). They’ve really struggled to stop opposing offenses, however, allowing over 40 points three times already this season. Signs of improvement are nonexistent, as they’ve allowed 35.7 points per game over their past three. 

Although Arizona State doesn’t play with any special pace, they’ve been able to effectively move the ball against every defense they’ve faced. They’ve averaged at least 5.7 yards per play in every game this season and shouldn’t be held down by this exposable Trojans defense allowing 6.1 yards per play. Quarterback Jayden Daniels is still one of the best signal-callers in the Pac-12, while Rachaad White and DeoMonte Trayanum lead a formidable rushing attack averaging nearly 200 yards per game.

College football parlays

Did you know that if you parlayed our USC vs. Arizona State picks, you could win $26.45 on a $10 bet?

Use our college football parlay calculator to create your own parlays and see their potential payouts.

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