After dropping their first game of the season, the Houston Cougars aim to bounce back as they take on the Oklahoma State Cowboys.
It’s been a rough year for the Cowboys, who have already parted ways with their head coach and are now on a four-game losing streak.
See my Houston vs. Oklahoma State predictions for the top wager, plus all our college football picks for this Big 12 showdown on Saturday, October 11.
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Houston vs Oklahoma State prediction
Houston vs Oklahoma State best bet: Houston -14.5 (-110)
Normally, I’d steer clear of a spread that big, but there’s no redeeming qualities coming out of this Oklahoma State team.
They have been crushed in back-to-back losses to Baylor (45-27) and last week to Arizona (41-13). In their four straight losses, only Tulsa failed to blow them out, winning 19-12.
They’re also down quarterback Zane Flores, who hurt his shoulder in the loss to Arizona.
That leaves them with freshman Banks Bowen, and Sam Jackson, who had converted to wide receiver last year while at Auburn. He replaced Flores against Arizona and threw for 27 yards on 3-for-6 passing.
Houston’s pivot problem is more encouraging, as Conner Weigman went into concussion protocol after leaving their 35-11 loss to Texas Tech in the second quarter.
After building a solid 4-0 mark, Weigman’s injury derailed the Cougars’ litmus test against its first ranked opponent on the year. He had thrown for 93 yards and a score before leaving the game, and Houston didn’t score another point.
Assuming he does play, he’ll lead a Houston Cougars offense averaging 27.2 points per game. Oklahoma State is averaging a paltry 16.4 points per contest, and their defense is 130th or worse in total yards and passing yards per game, while ranking 112th against the rush, at 179.4 per contest.
Houston vs Oklahoma State same-game parlay
During this current four-game losing slide, Oklahoma State has trailed by at least seven points in three of them. The only game they came out even was against Baylor, tied 7-7 after the first 15 minutes.
In Houston’s four wins, they came out of the opening quarter with at least a seven-point lead twice, and in a scoreless draw in another.
They should be in position to get ahead in this one on Saturday.
Houston vs Oklahoma State SGP
- Houston -14.5
- Under 46.5
- Houston -3.5 first quarter spread
Houston vs Oklahoma State game predictions
Houston vs Oklahoma State moneyline prediction
Houston ML (-620 at FanDuel)
I don’t see any way that Houston loses this game, even if Weigman were to sit out. So in that sense, a wager on the moneyline wouldn’t be the worst idea, but close, with little juice to make it worth your while.
A wager on OKST at +460? You might enjoy burning your money more than betting on the Cowboys.
Houston vs Oklahoma State spread prediction
Houston -14.5 (-110 at FanDuel)
If Conner Weigman suits up, he'll take charge of a Houston offense that's putting up 27.2 points per game. In contrast, Oklahoma State is struggling offensively, averaging just 16.4 points per game.
Defensively, the Cowboys rank 130th or worse in both total and passing yards allowed per game, and they're 112th against the run, giving up 179.4 rushing yards per contest.
Houston vs Oklahoma State Over/Under prediction
Under 46.5 points (-115 at FanDuel)
I don’t think this is a game where Houston wants to flex.
More than anything, I think they want to get out big early, perhaps open it up to the backups and get out of Stillwater without any serious injuries, as they have Arizona and no. 21 Arizona State on the horizon.
The Cowboys’ offense is in shambles, and their QB options don’t exactly instill some kind of offensive boost.
Their inability to put up points brings this score Under the total.
Houston vs Oklahoma State odds
- Spread: Houston -14.5 (-110) | Oklahoma State +14.5 (-110)
- Moneyline: Houston -620 | Oklahoma State +460
- Over/Under: Over 46.5 (-115) | Under 46.5 (-105)
Houston vs Oklahoma State trend to know
Oklahoma State has failed to cover the spread in nine of its last 10 games. Find more college football betting trends for Houston vs Oklahoma State.
How to watch Houston vs Oklahoma State
| Location | Boone Pickens Stadium, Stillwater, OK |
| Date | Saturday, October 11, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | TNT |
Houston vs Oklahoma State latest injuries
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Odds are correct at the time of publishing and are subject to change.
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